DNAH12 - dynein axonemal heavy chain 12 Gene

Also Known as DHC3; DLP3; HL19; DLP12; DNHD2; HDHC3; HL-19; DNAH7L; DNAHC3; DNAH12L; DNAHC12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201625

About DNAH12

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:57,293,700-57,556,034 (from NCBI)

This gene has 9 transcripts (splice variants), 278 orthologues and 15 paralogues. Biased expression in testis (RPKM 1.9), lung (RPKM 0.7) and 2 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of dynein complex. [provided by Alliance of Genome Resources, Apr 2022]

DNAH12 Products (2)

mRNA Protein Name
NM_001366028.2 NP_001352957.1 dynein axonemal heavy chain 12 isoform 4
NM_198564.4 NP_940966.2 dynein axonemal heavy chain 12 isoform 2

DNAH12 Protein Structure

DHC_N2

DHC_N2: Dynein heavy chain, N-terminal region 2 (675 - 1090)

AAA_6

AAA_6: Hydrolytic ATP binding site of dynein motor region D1 (1215 - 1442)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (1530 - 1672)

AAA_7

AAA_7: P-loop containing dynein motor region D3 (1856 - 2126)

AAA_8

AAA_8: P-loop containing dynein motor region D4 (2224 - 2299)

Dynein_heavy

Dynein_heavy: Dynein heavy chain and region D6 of dynein motor (2378 - 3089)

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  • 3092 a.a.
Protein Preferred Names Protein Names

dynein axonemal heavy chain 12

  • axonemal beta dynein heavy chain 12

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 3

  • Primary Ciliary Dyskinesia 3

  • CILD3

  • Ciliary Dyskinesia, Primary, 3, With Or Without Situs Inversus

  • Primary Ciliary Dyskinesia 3 With Or Without Situs Inversus

  • Ics3

  • Immotile Cilia Syndrome 3

  • Dyskinesia, Ciliary, Primary, 3
Sulfonamide Allergy
Papillary Craniopharyngioma

  • Craniopharyngioma, Papillary

  • Papillary Rathke'S Pouch Tumor

  • Craniopharyngioma Papillary
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03845 DNAH12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DNAH12 RGD RGD:619990
Canis familiaris DNAH12 VGNC VGNC:81894
Mus musculus DNAH12 MGD MGI:107720
Others DNAH12 NCBI