Terf2ip - telomeric repeat binding factor 2, interacting protein Gene

Also Known as Rap1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57321

Summary

Enables telomeric DNA binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of nucleobase-containing compound metabolic process; and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in embryo. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Terf2ip Products (1)

mRNA Protein Name
NM_020584.2 NP_065609.2 telomeric repeat-binding factor 2-interacting protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
20339076 MGI
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
23685356 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of DNA recombination at telomere IMP
IMP: Inferred from mutant phenotype
20339076 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
20622870 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
20622870 MGI
NOT involved in protection from non-homologous end joining at telomere IMP
IMP: Inferred from mutant phenotype
20339076 MGI
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20622869 MGI
involved in regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
20339076 MGI
involved in telomere maintenance via telomere lengthening IMP
IMP: Inferred from mutant phenotype
20339076 MGI
NOT involved in telomeric loop formation IMP
IMP: Inferred from mutant phenotype
24120135 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
15109494 MGI
located in chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
20622869 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
20622870 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
24062341 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20622870 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

telomeric repeat-binding factor 2-interacting protein 1

  • RAP1 homolog

  • TERF2-interacting telomeric protein 1

  • TRF2-interacting telomeric protein 1

  • TRF2-interacting telomeric protein Rap1

  • repressor/activator protein 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14374 TERF2IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Terf2ip NCBI NCBI:54386