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Art. -Nr.: HY-146420

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GRP78-IN-2

GRP78-IN-2 (Compound FL5) is a GRP78 (Glucose Regulated Protein 78 kDa) inhibitor. GRP78-IN-2 preferentially targeting cell surface GRP78 and shows potent antiangiogenic and anticancer activities without affecting other normal cells.

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CAS. Nr.: 1882875-63-9
Formel: C₂₉H₂₉NO₆
Molecular Weight:487.54

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

GRP78-IN-2 Chemical Structure

CAS. Nr.: 1882875-63-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Grp78

Alle HSP Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	CC₅₀	10 μM Compound: FL5	Cytotoxicity against human 786-0 cells assessed reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human 786-0 cells assessed reduction in cell viability after 48 hrs by MTT assay	[PMID: 32199134]
HUVEC	CC₅₀	10 μM Compound: FL5	Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32199134]
HUVEC	EC₅₀	1.514 μM Compound: FL5	Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32199134]

Chemical Information

CAS. Nr. 1882875-63-9
Molecular Weight 487.54
Formel C₂₉H₂₉NO₆
SMILES

COC1=CC(OC)=CC(C(OCC2=CC=C(C=C2)C3=C(C4=CC=CC=C4O3)C(NCC(C)C)=O)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Qiao Y, et al. Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy. Eur J Med Chem. 2020 May 1;193:112228. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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GRP78-IN-2

Alle HSP Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

GRP78-IN-2 Related Classifications

HY-146420 Related Classifications