LDDN-0003499
LDDN-0003499 is a Src family tyrosine kinase inhibitor and anti-inflammatory agent. LDDN-0003499 reduces basal and Aβ-stimulated levels of active, phosphorylated Lyn and Src kinases, and attenuates Aβ-stimulated secretion of pro-inflammatory cytokines TNFα and IL-6 in microglial cells. LDDN-0003499 can be used for the research of Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 331662-51-2
- Formel: C16H13Cl2N3O2
- Molecular Weight:350.20
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
IL-6 |
LDDN-0003499 (0.5 nM-50 μM; 24 h) shows no toxicity to mouse microglial BV2 cells[1].
LDDN-0003499 (0.5 nM-50 μM; 1 h) reduces the total protein phosphotyrosine level in murine microglial BV2 cells in a dose-dependent manner[1].
LDDN-0003499 (0.5 nM-50 μM; 1 h) dose-dependently inhibits the basal activity levels of phosphorylated Lyn and Src in mouse microglial BV2 cells[1].
LDDN-0003499 (0.5 nM-50 μM; 65 min) dose-dependently inhibits the Aβ-induced increase in the levels of activated phosphorylated Lyn and Src in mouse microglial BV2 cells[1].
LDDN-0003499 (0.5 nM-50 μM; 1 h) reduces Aβ-stimulated secretion of TNF-α and IL-6 in mouse microglial BV2 cells in a dose-dependent manner[1].
LDDN-0003499 (1 μM) exhibits moderately high NADPH-dependent clearance and low non-NADPH-dependent clearance in human and mouse liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:unstimulated murine microglial BV2 cells
-
Concentration:0.5 nM, 5 nM, 50 nM, 0.5 μM, 5 μM, 50 μM
-
Incubation Time:1 h
-
Result:Produced a dose-dependent decrease in active, phosphorylated Lyn (pLyn) and Src (pSrc) protein levels.
Did not alter phosphorylated levels of ERK, JNK, or p38.
-
Cell Line:Aβ-stimulated murine microglial BV2 cells
-
Concentration:0.5 nM, 5 nM, 50 nM, 0.5 μM, 5 μM, 50 μM
-
Incubation Time:1 h (pre-incubation); 5 min (co-incubation with 1 μM Aβ1-42)
-
Result:Attenuated the Aβ-stimulated increase in active, phosphorylated Lyn and Src protein levels.
Significantly attenuated the Aβ-stimulated increase in pLyn at 50 nM, while 500 nM was required for pSrc, demonstrating 10-fold selectivity for Lyn over Src in this paradigm.
Did not inhibit Aβ-stimulated increases in phosphorylated ERK.
Chemical Information
-
CAS. Nr. 331662-51-2
-
Molecular Weight 350.20
-
Formel C16H13Cl2N3O2
-
SMILES
ClC1=CC=C(NC=2N=CN=C3C=C(OC)C(OC)=CC32)C(Cl)=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LDDN-0003499 Related Classifications
HY-112369 Related Classifications
Powered by Bioz