50 Results for "

HT22 cells

" in MedChemExpress (MCE) Product Catalog:
Products (50)

50 Results for "HT22 cells" in MCE Product Catalog:

10
Paxilline
Paxilline
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10 Publications Verification
Art. -Nr.: HY-N6778
CAS. Nr.: 57186-25-1
Category:  

Alkaloids other families Microorganisms Neurological Disease Terpenoids Diterpenoids Plants Disease Research Fields Indole Alkaloids

Target:  

Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)

Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca 2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .
7
RGD peptide (GRGDNP)
RGD peptide (GRGDNP)
0 Images
7 Cited Publications
Art. -Nr.: HY-P1740
CAS. Nr.: 114681-65-1
Target:  

Integrin Apoptosis Caspase

Forschungsgebiete:  

Inflammation/Immunology

RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation .
7
RGD peptide (GRGDNP) TFA
RGD peptide (GRGDNP) TFA
0 Images
7 Cited Publications
Art. -Nr.: HY-P1740A
Target:  

Integrin Apoptosis

Forschungsgebiete:  

Inflammation/Immunology Cancer

RGD peptide (GRGDNP) TFA is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) TFA competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) TFA promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) TFA plays an important role in cell adhesion, migration, growth, and differentiation .
2
CMS-121
CMS-121
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2 Cited Publications
Art. -Nr.: HY-135981
CAS. Nr.: 1353224-53-9
Reinheit:  98.30%
Target:  

Acetyl-CoA Carboxylase

Forschungsgebiete:  

Neurological Disease Inflammation/Immunology

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities .
2
PDCD4-IN-1
PDCD4-IN-1
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2 Cited Publications
Art. -Nr.: HY-153383
CAS. Nr.: 494763-64-3
Reinheit:  99.65%
Target:  

Programmed Cell Death 4 (PDCD4)

Forschungsgebiete:  

Cancer

PDCD4-IN-1(compound 20031600) is a PDCD4 inhibitor with a Kd value of 350 nM, which can promote the expression of BDNF in hippocampal neuron cell HT-22 .
1
NE-100 hydrochloride
NE-100 hydrochloride
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1 Cited Publications
Art. -Nr.: HY-101484A
CAS. Nr.: 149409-57-4
Reinheit:  98.20%
Target:  

Sigma Receptor ATF6

Forschungsgebiete:  

Neurological Disease

NE-100 hydrochloride is an orally active and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 hydrochloride can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE-100 hydrochloride can be used for research on nervous system diseases .
1
Kirenol
Kirenol
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1 Cited Publications
Art. -Nr.: HY-N0559
CAS. Nr.: 52659-56-0
Category:  

Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae

Target:  

Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad

Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis .
1
B-355252
B-355252
0 Images
1 Cited Publications
Art. -Nr.: HY-120553
CAS. Nr.: 1261576-81-1
Reinheit:  ≥99.0%
Target:  

Apoptosis

Forschungsgebiete:  

Neurological Disease

B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD) .
1
4-Hydroxyestrone
4-Hydroxyestrone
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1 Cited Publications
Art. -Nr.: HY-W009300
CAS. Nr.: 3131-23-5
Synonyms: 4-OHE1
Category:  

Neurological Disease Animals Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)

4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .
Homogentisic acid
Homogentisic acid
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Art. -Nr.: HY-113283
CAS. Nr.: 451-13-8
Reinheit:  99.46%
Category:  

Other disease Ketones, Aldehydes, Acids Disease markers Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:  

Amyloid-β Natriuretic Peptide Receptor (NPR) α-synuclein Transthyretin (TTR) Claudin

Homogentisic acid is an orally active, blood-brain barrier-permeable amyloidogenic compound that functions as both an amyloid component and a pigment precursor. Accumulation of homogentisic acid downregulates tight junction proteins (such as claudin-5, occludin, ZO-1) and impairs blood-brain barrier integrity. Homogentisic acid and its oxidation product benzoquinone acetic acid not only induce the aggregation and fibrosis of multiple proteins (such as Aβ1-42, α-synuclein, SAA, Transthyretin (TTR), atrial natriuretic peptide), but also trigger oxidative stress, damage to the Wnt/β-catenin pathway, and neurotoxicity, leading to ochronosis pigment deposition and synaptic dysfunction. At specific concentrations, homogentisic acid exerts no cytotoxicity or genotoxicity on human peripheral blood lymphocytes, and even counteracts the genotoxicity induced by Irinotecan (HY-16562). Homogentisic acid serves as an important tool molecule for investigating the mechanisms of diseases including ochronosis, secondary amyloidosis, Alzheimer's disease, and colorectal cancer .
Kuwanon G
Kuwanon G
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Art. -Nr.: HY-N4247
CAS. Nr.: 75629-19-5
Category:  

Infection Flavonoids Flavones Phenols Polyphenols Plants Moraceae Disease Research Fields Morus alba Linn.

Target:  

Bombesin Receptor Bacterial Apoptosis Reactive Oxygen Species (ROS) PI3K Akt GSK-3 MMP mTOR NF-κB LXR

Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis .
Peonidin-3-O-galactoside chloride
Peonidin-3-O-galactoside chloride
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Art. -Nr.: HY-126411
CAS. Nr.: 28148-89-2
Reinheit:  96.75%
Category:  

Anthocyans other families Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Lipase ATP Synthase

Peonidin-3-O-galactoside chloride is an anthocyanin with antioxidant properties and blood-brain barrier permeability. Peonidin-3-O-galactoside chloride inhibits pancreatic lipase, with an IC50 value of 23.2 μg/mL against porcine pancreatic lipase. Peonidin-3-O-galactoside chloride mediates neuroprotection, regulates glucose metabolism, protects cells from high glucose-induced damage, promotes glucose uptake and increases ATP production. Peonidin-3-O-galactoside (chloride) can be used in the research of obesity and neurodegenerative diseases .
Hydroxytyrosol acetate
Hydroxytyrosol acetate
0 Images
Art. -Nr.: HY-N6043
CAS. Nr.: 69039-02-7
Category:  

Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Reactive Oxygen Species (ROS) Bacterial SARS-CoV Estrogen Receptor/ERR

Hydroxytyrosol acetate is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol acetate not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol acetate effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol acetate significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol acetate has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
Aftin-5
Aftin-5
0 Images
Art. -Nr.: HY-136674
CAS. Nr.: 1461717-05-4
Reinheit:  99.70%
Target:  

Amyloid-β

Forschungsgebiete:  

Neurological Disease

Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively .
JGB-1-155
JGB-1-155
0 Images
Art. -Nr.: HY-163280
CAS. Nr.: 3011930-28-9
Target:  

NAMPT

Forschungsgebiete:  

Neurological Disease

JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 μM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD + in THP-1 human monocytes. JGB-1-155 attenuates TNFα-induced ROS in HT-22 cells .
(1R,3S)-RSL3
(1R,3S)-RSL3
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Art. -Nr.: HY-100218B
CAS. Nr.: 1219810-13-5
Reinheit:  99.78%
Target:  

Glutathione Peroxidase Ferroptosis

Forschungsgebiete:  

Cancer

(1R,3S)-RSL3 is the less active (1R,3S)-enantiomer of RSL3 ((1S,3R)-RSL3). (1R,3S)-RSL3 and RSL3 induce cell death in HT22 wild-type cells with EC50 values of 5.2 µM and 0.004 µM, rspectively .
Tet1 peptide
Tet1 peptide
0 Images
Art. -Nr.: HY-P10998
CAS. Nr.: 270919-17-0
Target:  

TET Protein

Forschungsgebiete:  

Neurological Disease

Tet1 peptide is a peptide that specifically binds to neurons. Tet1 peptide binds to GT1B ganglioside and trisialoganglioside clostridial toxin receptor on the surface of neuronal cells, and can be used in peptide conjugation and drug delivery research .
Aβ42 agonist-2
Aβ42 agonist-2
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Art. -Nr.: HY-149764
CAS. Nr.: 6314-40-5
Reinheit:  99.92%
Target:  

Amyloid-β

Forschungsgebiete:  

Neurological Disease

Aβ42 agonist-2 (compound 7b) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-2 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-2 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells .
Sanggenol O
Sanggenol O
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Art. -Nr.: HY-N9966
CAS. Nr.: 426211-27-0
Category:  

Flavonoids Flavonones Morus alba L. Plants Moraceae

Target:  

Others

Sanggenol O? is an active product that can be extracted from Morus alba. Sanggenol O? has hepatoprotective and neuroprotective activities with EC50s more than 80 μM in HepG2 and HT22 cells .
Juncuenin D
Juncuenin D
0 Images
Art. -Nr.: HY-N8464
CAS. Nr.: 1161681-24-8
Category:  

Natural Products Juncaceae Plants Juncus acutus L.

Target:  

Bacterial

Juncuenin D induces caspase-3-mediated cytotoxicity in HT22 cells. Juncuenin D also has anti-bacterial activity against MRSA strains. Juncuenin D can be isolated from J. effusus .
Assay Types