5'-3' exonuclease PLD3

Definition:

5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.

References:

[1]. Pietro Fazzari, et al. PLD3 gene and processing of APP. Nature. 2017 Jan 25;541(7638):E1-E2. [Content Brief]

[2]. Adriana Carolina Gonzalez, et al. PLD3 and spinocerebellar ataxia. Brain. 2018 Nov 1;141(11):e78. [Content Brief]

[3]. Mary Osisami, et al. A role for phospholipase D3 in myotube formation. PLoS One. 2012;7(3):e33341. [Content Brief]

[4]. Aamir S Mukadam, et al. Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing. Cell Mol Life Sci. 2018 Jul;75(14):2613-2625. [Content Brief]

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