EZH inhibitory protein

Definition:

Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2. Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity).

References:

[1]. Roberta Ragazzini, et al. EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Nat Commun. 2019 Aug 26;10(1):3858. [Content Brief]

[2]. Siddhant U Jain, et al. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019 May 13;10(1):2146. [Content Brief]

[3]. Kristian W Pajtler, et al. Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. Acta Neuropathol. 2018 Aug;136(2):211-226. [Content Brief]

[4]. Jens-Martin Hübner, et al. EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. Neuro Oncol. 2019 Jul 11;21(7):878-889. [Content Brief]

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