Hepatoma-derived growth factor

Definition:

[Isoform 1]: Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein.; [Isoform 2]: Does not have mitogenic activity for fibroblasts. Does not bind heparin.; [Isoform 3]: Has mitogenic activity for fibroblasts. Heparin-binding protein.

References:

[1]. Jun Yang, et al. Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain. BMC Mol Biol. 2007 Oct 31;8:101. [Content Brief]

[2]. Shih-Che Sue, et al. Solution structure and heparin interaction of human hepatoma-derived growth factor. J Mol Biol. 2004 Nov 5;343(5):1365-77. [Content Brief]

[3]. Jessica Nüße, et al. Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton. Biol Chem. 2016 May;397(5):417-36. [Content Brief]

[4]. Yoshihiko Kishima, et al. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals. J Biol Chem. 2002 Mar 22;277(12):10315-22. [Content Brief]

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