HOXB-AS3 peptide
Definition:
Blocks the binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1 RGG-box motif. This inhibits inclusion of exon 9 and promotes inclusion of exon 10, suppressing formation of the PKM M2 isoform and promoting production of the M1 isoform. Also suppresses HNRNPA1-mediated processing of microRNA 18a (miR-18a). Promotes MYC stability through interaction with IGF2BP2.
References:
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[1]. Jin-Zhou Huang, et al. A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth. Mol Cell. 2017 Oct 5;68(1):171-184.e6. [Content Brief]
[2]. Fei Leng, et al. A micro-peptide encoded by HOXB-AS3 promotes the proliferation and viability of oral squamous cell carcinoma cell lines by directly binding with IGF2BP2 to stabilize c-Myc. Oncol Lett. 2021 Oct;22(4):697. [Content Brief]
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