Soft tissue sarcomas

Definition:

Soft-tissue sarcomas (STS) are a rare and heterogeneous group of tumors with mesenchymal origin, including muscle, endothelium, cartilage. Several common STSs have recognized translocations, which represent clinical targets. In addition to translocations, other genomic changes and epigenetic mechanisms have been shown to be involved in the histogenesis of STS as well as other cancers.

References:

[1]. Brian E Walczak, et al. Sarcoma chemotherapy. J Am Acad Orthop Surg. 2013 Aug;21(8):480-91. [Content Brief]

[2]. Domagoj Ante Vodanovich, et al. Soft-tissue Sarcomas. Indian J Orthop. 2018 Jan-Feb;52(1):35-44. [Content Brief]

[3]. J F Moley, et al. Soft-tissue sarcomas. Surg Clin North Am. 2000 Apr;80(2):687-708. [Content Brief]

[4]. Megan Meyer, et al. First-Line Therapy for Metastatic Soft Tissue Sarcoma. Curr Treat Options Oncol. 2019 Jan 24;20(1):6. [Content Brief]

[5]. Ravin Ratan, et al. Chemotherapy for soft tissue sarcoma. Cancer. 2016 Oct;122(19):2952-60. [Content Brief]

[6]. Rosanna Wustrack, et al. Molecular Markers in Bone and Soft-Tissue Tumors. JBJS Rev. 2016 Aug 30;4(8):e5. [Content Brief]

[7]. Ylermi Soini, et al. Epigenetic and genetic changes in soft tissue sarcomas: a review. APMIS. 2016 Nov;124(11):925-934. [Content Brief]

[8]. Yoshinao Oda, et al. Soft tissue sarcomas: From a morphological to a molecular biological approach. Pathol Int. 2017 Sep;67(9):435-446. [Content Brief]

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