ATG16L2 - autophagy related 16 like 2 Gene

Also Known as WDR80; ATG16B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89849

About ATG16L2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,814,411-72,843,740 (from NCBI)

This gene has 21 transcripts (splice variants), 171 orthologues and 1 paralogue. Broad expression in spleen (RPKM 22.5), skin (RPKM 19.9) and 24 other tissues.

Summary

Predicted to be involved in autophagosome assembly and negative stranded viral RNA replication. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ATG16L2 Products (2)

mRNA Protein Name
NM_001318766.2 NP_001305695.1 protein Atg16l2 isoform 2
NM_033388.2 NP_203746.1 protein Atg16l2 isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
part of Atg12-Atg5-Atg16 complex IPI
IPI: Inferred from physical interaction
23202584 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG16L2 Protein Structure

ATG16

ATG16: Autophagy protein 16 (ATG16) (14 - 204)

WD40

WD40: WD domain, G-beta repeat (331 - 364)

WD40

WD40: WD domain, G-beta repeat (414 - 450)

WD40

WD40: WD domain, G-beta repeat (503 - 530)

WD40

WD40: WD domain, G-beta repeat (554 - 576)

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  • 619 a.a.
Protein Preferred Names Protein Names

protein Atg16l2

  • APG16-like 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01144 ATG16L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ATG16L2 VGNC VGNC:38220
Mus musculus ATG16L2 MGD MGI:1920933
Macaca mulatta ATG16L2 VGNC VGNC:70130
Rattus norvegicus ATG16L2 RGD RGD:1311400
Felis catus ATG16L2 VGNC VGNC:59999
Bos taurus ATG16L2 VGNC VGNC:26254
Others ATG16L2 NCBI