6BrCaQ-C10-TPP
6BrCaQ-C10-TPP is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity in various human cancer cells (IC50=0.008-0.30 μM). 6BrCaQ-C10-TPP can also induces mitochondrial membrane disturbance.
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- CAS No.: 3036044-73-9
- Formule: C45H47Br2N2O3P
- Masse moléculaire:854.65
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
<0.1 μM
Compound: 3a, 6BrCaQ-C10-TPP
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Cytotoxicity against human HT-29 cells assessed as reduction in viable cells incubated for 72 hrs by trypan blue staining based optical microscopic analysis relative to control
Cytotoxicity against human HT-29 cells assessed as reduction in viable cells incubated for 72 hrs by trypan blue staining based optical microscopic analysis relative to control
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[PMID: 34952432] |
| HT-29 | IC50 |
<1 μM
Compound: 3a, 6BrCaQ-C10-TPP
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Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 34952432] |
| MDA-MB-231 | GI50 |
0.008 μM
Compound: 3a, 6BrCaQ-C10-TPP
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Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay
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[PMID: 34952432] |
| MDA-MB-231 | IC50 |
0.008 μM
Compound: 3a, 6BrCaQ-C10-TPP
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Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by Celltiter Glo assay
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[PMID: 34952432] |
Chemical Information
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CAS No. 3036044-73-9
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Masse moléculaire 854.65
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Formule C45H47Br2N2O3P
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SMILES
CN1C(C(NC(C2=CC=C(C=C2)OCCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)=CC6=CC(Br)=CC=C61)=O.[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6BrCaQ-C10-TPP Related Classifications
HY-144831 Related Classifications
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