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Pifithrin-α hydrobromide

(Synonyms: Pifithrin hydrobromide; PFTα hydrobromide)
102 Cited Publications
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Based on 102 publication(s) in Google Scholar

Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.

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  • Pureté: 99.94%
  • CAS No.: 63208-82-2
  • Formule: C16H19BrN2OS
  • Masse moléculaire:367.30
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    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Pifithrin-α hydrobromide Chemical Structure
    Pifithrin-α hydrobromide Chemical Structure
  • Experimental Validation Results for Pifithrin-α hydrobromide
  • Experimental Validation Results for Pifithrin-α hydrobromide
  • Experimental Validation Results for Pifithrin-α hydrobromide
  • Experimental Validation Results for Pifithrin-α hydrobromide
CAS No.: 63208-82-2
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  • Pifithrin-α hydrobromide Chemical Structure
    Pifithrin-α hydrobromide Chemical Structure
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  • 1/16

    Pifithrin-α hydrobromide purchased from MedChemExpress. Usage Cited in: Neurosci Lett. 2023 Mar 13:800:137125. [Abstract]

    Customer Validation
     Pifithrin-α hydrobromide (PFT-α; 0.5 μM; 0, 24, 48 h) reverses the inhibition of NSC cell proliferation (SV2A knockdown promotes NSCs apoptosis) (fig C) and reduces cleaved caspase 3 (CC3) expression (fig D) induced by SV2A knockdown.

  • 1/16

    Pifithrin-α hydrobromide purchased from MedChemExpress. Usage Cited in: Mol Nutr Food Res. 2018 Aug;62(16):e1800164. [Abstract]

    Customer Validation
     PFT-α, a pharmacological p53 inhibitor, inhibits the expression of frataxin in HepG2 cells. Under the treatment of free fatty acids (FFAs), the frataxin are further decreased by PFT-α.

  • 1/16

    Pifithrin-α hydrobromide purchased from MedChemExpress. Usage Cited in: Am J Cancer Res. 2018 Sep 1;8(9):1697-1711. [Abstract]

    Customer Validation
     Pifithrin-α hydrobromide (PFT) treatment inhibits Atovaquone (ATO)-induced upregulation of p53, p21, and cleavage of PARP, as well as downregulation of CDK2.

  • 1/16

    Pifithrin-α hydrobromide purchased from MedChemExpress. Usage Cited in: Front Genet. 2018 Aug 31:9:320. [Abstract]

    Customer Validation
     Western blot analysis of the expression of p53 and caspase-3 after intrathecal administration of Pifithrin-α on day 7 after chronic constriction injury (CCI). The fold change of p53 and caspase-3 levels is normalized to the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) level.

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