Loss of SV2A promotes human neural stem cell apoptosis via p53 signaling

  • Neurosci Lett. 2023 Feb 11;137125. doi: 10.1016/j.neulet.2023.137125.
Hongxiang Yu  1 ,  Yingying Han  1 ,  Can Cui  1 ,  Bei Zhang  2 ,  Gang Li  3
Affiliations
  • 1. Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
  • 2. Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: [email protected].
  • 3. Department of Neurology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: [email protected].
PMID: 36780942 DOI: 10.1016/j.neulet.2023.137125
Abstract

This study investigated the role of synaptic vesicle protein 2A (SV2A) in the regulation of human induced pluripotent stem cell-derived neural stem cells (NSCs). SV2A was highly expressed in NSCs. SV2A knockdown promotes Apoptosis, which was associated with an upregulation of genes involved in p53 signaling as determined by transcriptome analysis. Treatment with the small molecule p53 inhibitor pifithrin-α reversed the promotion of NSC Apoptosis induced by loss of SV2A. These results demonstrate that SV2A plays an important role in regulating NSC survival via the p53 signaling pathway.

Keywords
Apoptosis; Neural stem cell; Synaptic vesicle protein 2A; p53 signaling pathway.
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