Adenine-d
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Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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- Pureté: 99.90%
- CAS No.: 109923-52-6
- Formule: C5H4DN5
- Masse moléculaire:136.13
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 109923-52-6
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Unlabeled Cas 73-24-5
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Appearance Solid
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Masse moléculaire 136.13
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Formule C5H4DN5
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Color White to off-white
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SMILES
[2H]C1=NC(N)=C2N=CNC2=N1
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Synonyms
6-Aminopurine-d1; Vitamin B4-d1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
1 M HCl : 20 mg/mL (146.92 mM; Need ultrasonic)
DMSO : ≥ 10 mg/mL (73.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (14.69 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. ;ORO J, et al. Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide. Arch Biochem Biophys. 1961 Aug;94:217-27.;Griffiths AJF, et al. An Introduction to Genetic Analysis. 7th edition. New York: W. H. Freeman; 2000. Structure of DNA.;Reader V. The assay of vitamin B(4). Biochem J. 1930;24(6):1827-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO / 1 M HCl | 1 mM | 7.3459 mL | 36.7296 mL | 73.4592 mL | 183.6480 mL |
| 5 mM | 1.4692 mL | 7.3459 mL | 14.6918 mL | 36.7296 mL | |
| 10 mM | 0.7346 mL | 3.6730 mL | 7.3459 mL | 18.3648 mL | |
| DMSO / 1 M HCl | 15 mM | 0.4897 mL | 2.4486 mL | 4.8973 mL | 12.2432 mL |
| 20 mM | 0.3673 mL | 1.8365 mL | 3.6730 mL | 9.1824 mL | |
| 25 mM | 0.2938 mL | 1.4692 mL | 2.9384 mL | 7.3459 mL | |
| 30 mM | 0.2449 mL | 1.2243 mL | 2.4486 mL | 6.1216 mL | |
| 40 mM | 0.1836 mL | 0.9182 mL | 1.8365 mL | 4.5912 mL | |
| 50 mM | 0.1469 mL | 0.7346 mL | 1.4692 mL | 3.6730 mL | |
| 60 mM | 0.1224 mL | 0.6122 mL | 1.2243 mL | 3.0608 mL | |
| 1 M HCl | 80 mM | 0.0918 mL | 0.4591 mL | 0.9182 mL | 2.2956 mL |
| 100 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.8365 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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