BTK-IN-48
BTK-IN-48 is a BTK inhibitor with an IC50 of 1.14 μM. BTK-IN-48 inhibits recombinant BTK and c-Src, and exerts moderate inhibitory effects on LCK, BMX/ETK, FLT3 and PIM1. BTK-IN-48 can be used in the research of B-cell malignancies and autoimmune diseases.
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- CAS No.: 3114078-55-3
- Formule: C19H15N3O3
- Masse moléculaire:333.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
BTK-IN-48 (Compound 6b) potently inhibits recombinant BTK with an IC50 of 1.14 μM, and achieves an inhibition rate of 88.6% at a single concentration of 10 μM[1].
BTK-IN-48 (10 μM) potently inhibits recombinant BTK and c-Src at a concentration of 10 μM, and exerts moderate inhibitory effects on LCK, BMX/ETK, FLT3 and PIM1[1].
BTK-IN-48 (0-40 μM; 4 days) exerts mild growth inhibition on RPMI-1788 and RPMI-7666 normal B cells, but does not induce significant cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RPMI-1788, RPMI-7666 cells
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Concentration:0, 10, 20, 30, 40 μM
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Incubation Time:4 days
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Result:Reduced viability of RPMI-1788 cells to ~60% of untreated controls at 40 μM.
Reduced viability of RPMI-7666 cells to ~85% of untreated controls at 40 μM.
Did not cause significant increase in ToPro3-positive (dead) cells across all tested concentrations, with cell death remaining below 5% for both cell lines.
Chemical Information
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CAS No. 3114078-55-3
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Masse moléculaire 333.34
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Formule C19H15N3O3
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SMILES
COC(C=C1)=CC=C1N(C(C2=CC=C(O)C=C2O)=N3)C4=C3C=CC=N4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTK-IN-48 Related Classifications
HY-182293 Related Classifications
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