D-Tagatose
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D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.
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- Pureté: 99.94%
- CAS No.: 87-81-0
- Formule: C6H12O6
- Masse moléculaire:180.16
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Human Endogenous Metabolite |
D-Tagatose was synthesized from starch via an ATP-free in vitro multi-enzyme pathway, with high yield enabled by the final irreversible dephosphorylation step[1].
D-Tagatose does not increase mutation frequency in mouse L5178Y lymphoma cancer cells, with or without metabolic activation[2].
D-Tagatose is thermally stable in milk and lemonade, with minimal degradation and preserved prebiotic activity during processing and storage[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
D-Tagatose (sole carbohydrate source in diet; dietary; ad libitum; 16 weeks), when substituted for sucrose in hypercholesterolemic mouse diets, prevents the development of obesity, hyperglycemia, hyperlipidemia, and atherosclerosis observed with sucrose feeding[2].
D-Tagatose produces antidiabetic effects in the SHR/N-cp rat model of type 2 diabetes[2].
D-Tagatose (0.9-1.8 g/(rat·d); oral; mixed with basal diet; 21-day adaptation period; 40-41-day balance period) provides effectively zero net metabolizable energy to growing male Wistar rats, with a calculated NEVs of -0.5 kJ/g that is not significantly different from zero[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (male, initial weight 80-100 g)[3]
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Dosage:0.9 g/(rat·d); 1.8 g/(rat·d)
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Administration:oral (mixed with basal diet; 21-day adaptation period; 40- or 41-day balance period)
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Result:Did not significantly alter live weight gain during the balance period.
Did not increase energy gain as protein or fat, unlike sucrose.
Yielded a calculated net metabolizable energy value (NEVs) of -0.5 kJ/g (SEM ±2.2 kJ/g), which was not significantly different from zero.
Elevated metabolizable energy for maintenance plus substrate-induced energy losses by 24 kJ/g average protein mass after adjustment for balance period duration and lean mass.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 87-81-0
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Appearance Solid
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Masse moléculaire 180.16
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Formule C6H12O6
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Color White to off-white
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SMILES
OCC([C@@H](O)[C@@H](O)[C@H](O)CO)=O
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Synonyms
D-(-)-Tagatose
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (555.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Fan L, et al. Biosynthesis of a healthy natural sugar D-tagatose: advances and opportunities. Crit Rev Biotechnol. 2025;45(7):1492-1507. [Content Brief]
[2]. Guerrero-Wyss M, et al. D-Tagatose Is a Promising Sweetener to Control Glycaemia: A New Functional Food. Biomed Res Int. 2018;2018:8718053. Published 2018 Jan 9. [Content Brief]
[3]. Livesey G, et al. D-tagatose is a bulk sweetener with zero energy determined in rats. J Nutr. 1996 Jun;126(6):1601-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.5506 mL | 27.7531 mL | 55.5062 mL | 138.7655 mL |
| 5 mM | 1.1101 mL | 5.5506 mL | 11.1012 mL | 27.7531 mL | |
| 10 mM | 0.5551 mL | 2.7753 mL | 5.5506 mL | 13.8766 mL | |
| 15 mM | 0.3700 mL | 1.8502 mL | 3.7004 mL | 9.2510 mL | |
| 20 mM | 0.2775 mL | 1.3877 mL | 2.7753 mL | 6.9383 mL | |
| 25 mM | 0.2220 mL | 1.1101 mL | 2.2202 mL | 5.5506 mL | |
| 30 mM | 0.1850 mL | 0.9251 mL | 1.8502 mL | 4.6255 mL | |
| 40 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4691 mL | |
| 50 mM | 0.1110 mL | 0.5551 mL | 1.1101 mL | 2.7753 mL | |
| 60 mM | 0.0925 mL | 0.4626 mL | 0.9251 mL | 2.3128 mL | |
| 80 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7346 mL | |
| 100 mM | 0.0555 mL | 0.2775 mL | 0.5551 mL | 1.3877 mL |
D-Tagatose Related Classifications
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