Gnat1 - G protein subunit alpha transducin 1 Gene

Also Known as Hg1f; Ird1; Ird2; irdc; irdr; Gnat-1; Tralpha; transducin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14685

Summary

Enables G-protein beta/gamma-subunit complex binding activity and GTPase activity. Acts upstream of or within several processes, including cellular response to electrical stimulus; detection of light stimulus; and eye development. Located in photoreceptor connecting cilium; photoreceptor inner segment; and photoreceptor outer segment. Is expressed in brain; photoreceptor layer outer segment; retina; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1G; congenital stationary night blindness autosomal dominant 3; and night blindness. Orthologous to human GNAT1 (G protein subunit alpha transducin 1). [provided by Alliance of Genome Resources, Apr 2022]

Gnat1 Products (1)

mRNA Protein Name
NM_008140.3 NP_032166.1 guanine nucleotide-binding protein G(t) subunit alpha-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables G-protein beta/gamma-subunit complex binding IDA
IDA: Inferred from direct assay
17881533 MGI
enables GTPase activity IDA
IDA: Inferred from direct assay
17881533 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17881533 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
14712229 MGI
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15073279 MGI
acts upstream of or within background adaptation IMP
IMP: Inferred from mutant phenotype
24373883 MGI
acts upstream of or within cell population proliferation IDA
IDA: Inferred from direct assay
14712229 MGI
acts upstream of or within cellular response to electrical stimulus IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within detection of light stimulus IDA
IDA: Inferred from direct assay
19815523 MGI
acts upstream of or within detection of light stimulus IGI
IGI: Inferred from genetic interaction
19815523 MGI
acts upstream of or within detection of light stimulus IMP
IMP: Inferred from mutant phenotype
19815523 MGI
acts upstream of or within detection of light stimulus involved in visual perception IMP
IMP: Inferred from mutant phenotype
18171936 MGI
acts upstream of or within dopamine secretion IMP
IMP: Inferred from mutant phenotype
30799247 MGI
acts upstream of or within eye photoreceptor cell development IMP
IMP: Inferred from mutant phenotype
16249514 MGI
acts upstream of or within neural tissue regeneration IGI
IGI: Inferred from genetic interaction
30111842 MGI
acts upstream of or within phototransduction IMP
IMP: Inferred from mutant phenotype
11095744 MGI
acts upstream of or within response to light intensity IMP
IMP: Inferred from mutant phenotype
20844144 MGI
acts upstream of or within response to light stimulus IDA
IDA: Inferred from direct assay
19815523 MGI
acts upstream of or within response to light stimulus IGI
IGI: Inferred from genetic interaction
19815523 MGI
acts upstream of or within response to light stimulus IMP
IMP: Inferred from mutant phenotype
19815523 MGI
acts upstream of or within response to organic cyclic compound IMP
IMP: Inferred from mutant phenotype
31537864 MGI
acts upstream of or within retina development in camera-type eye IGI
IGI: Inferred from genetic interaction
21124780 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within retinal cone cell differentiation IDA
IDA: Inferred from direct assay
19815523 MGI
acts upstream of or within retinal cone cell differentiation IGI
IGI: Inferred from genetic interaction
19815523 MGI
acts upstream of or within retinal cone cell differentiation IMP
IMP: Inferred from mutant phenotype
19815523 MGI
acts upstream of or within retinal rod cell differentiation IDA
IDA: Inferred from direct assay
19815523 MGI
acts upstream of or within retinal rod cell differentiation IGI
IGI: Inferred from genetic interaction
19815523 MGI
acts upstream of or within retinal rod cell differentiation IMP
IMP: Inferred from mutant phenotype
19815523 MGI
acts upstream of or within sensory perception of umami taste IMP
IMP: Inferred from mutant phenotype
15342734 MGI
acts upstream of or within visual behavior IMP
IMP: Inferred from mutant phenotype
20844144 MGI
acts upstream of or within visual perception IGI
IGI: Inferred from genetic interaction
30111842 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
16603466 MGI
Cellular Component GO Annotation Evidence Références Source
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
17881533 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
31696965 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
18367617 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(t) subunit alpha-1

  • guanine nucleotide binding protein, alpha transducing 1

  • heterotrimeric guanine nucleotide-binding protein 1f

  • transducin alpha-1 chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05541 GNAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnat1 NCBI NCBI:2779