TSKU - tsukushi, small leucine rich proteoglycan Gene

Also Known as TSK; E2IG4; LRRC54

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25987

About TSKU

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,782,280-76,798,144 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 22 paralogues. Broad expression in liver (RPKM 39.4), fat (RPKM 26.7) and 20 other tissues.

Summary

Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including animal organ development; Cholesterol efflux; and Cholesterol homeostasis. Predicted to act upstream of or within several processes, including ciliary body morphogenesis; negative regulation of Wnt signaling pathway; and telencephalon development. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TSKU Products (5)

mRNA	Protein	Name
NM_001258210.2	NP_001245139.1	tsukushi isoform b precursor
NM_001318477.2	NP_001305406.1	tsukushi isoform a precursor
NM_001318478.2	NP_001305407.1	tsukushi isoform b precursor
NM_001318479.2	NP_001305408.1	tsukushi isoform b precursor
NM_015516.4	NP_056331.2	tsukushi isoform b precursor

TSKU Protein Structure

LRR_8

LRR_1

0
100
200
300
353 a.a.

Protein Preferred Names	Protein Names
tsukushi	E2-induced gene 4 protein

Related Diseases

Diseases	Alias
Epilepsy, Idiopathic Generalized 4	EIG4 Epilepsy, Idiopathic Generalized, Susceptibility To 4 Idiopathic Generalized Epilepsy 4 Epilepsy, Idiopathic Generalized, Susceptibility To, 4 Epilepsy, Idiopathic Generalized Locus On Chromosome 10 Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 10
Barre-Lieou Syndrome	Cervicocranial Syndrome Posterior Cervical Sympathetic Syndrome
Scheuermann Disease	Scheuermann'S Disease Spinal Osteochondrosis Juvenile Osteochondrosis Of Spine Familial Scheuermann Disease Familial Scheuermann Juvenile Kyphosis Familial Spinal Osteochondrosis Scheuermann Juvenile Kyphosis Juvenile Osteochondritis Of The Spine Juvenile Osteochondrosis Of Scheurermann Scheuermann'S Kyphosis Sherman'S Disease Juvenile Kyphosis Scheuermann Kyphosis [X]Spinal Osteochondrosis, Unspecified
N Syndrome	NSX Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia
Bardet-Biedl Syndrome 10	BBS10 Bardet-Biedl Syndrome Bbs Bardet-Biedl Syndrome, Type 10
Gallbladder Benign Neoplasm
Myasthenic Syndrome, Congenital, 21, Presynaptic	Congenital Myasthenic Syndrome 21 CMS21 Congenital Myasthenic Syndrome 21, Presynaptic
Gallbladder Adenoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15152	TSKU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSKU	RGD	RGD:1359311
Bos taurus	TSKU	VGNC	VGNC:54896
Canis familiaris	TSKU	VGNC	VGNC:52857
Mus musculus	TSKU	MGD	MGI:2443855
Macaca mulatta	TSKU	VGNC	VGNC:79746