Gabra1 - gamma-aminobutyric acid type A receptor subunit alpha 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29705

Summary

Enables diazepam binding activity. Contributes to GABA Receptor activity. Involved in GABAergic synaptic transmission and cellular response to histamine. Located in membrane. Is integral component of plasma membrane. Part of GABA Receptor complex. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 19 and idiopathic generalized epilepsy 13. Orthologous to human GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1). [provided by Alliance of Genome Resources, Apr 2022]

Gabra1 Products (1)

mRNA Protein Name
NM_183326.2 NP_899155.1 gamma-aminobutyric acid receptor subunit alpha-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
contributes to GABA receptor activity IDA
IDA: Inferred from direct assay
12930820 RGD
enables GABA-A receptor activity IDA
IDA: Inferred from direct assay
9882711 RGD
enables GABA-gated chloride ion channel activity IDA
IDA: Inferred from direct assay
9882711 RGD
enables diazepam binding IDA
IDA: Inferred from direct assay
1346133 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: Inferred from direct assay
22539847 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
22539847 RGD
enables organic cyclic compound binding IPI
IPI: Inferred from physical interaction
1346133 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16890252 RGD
Biological Process GO Annotation Evidence Références Source
involved in cellular response to histamine IDA
IDA: Inferred from direct assay
18281286 RGD
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
22428005 RGD
involved in response to methamphetamine hydrochloride IEP
IEP: Inferred from expression pattern
30275762 RGD
involved in synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
12930820 RGD
Cellular Component GO Annotation Evidence Références Source
part of GABA receptor complex IDA
IDA: Inferred from direct assay
12930820 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
8613776 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
8613776 RGD
located in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
9464994 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-aminobutyric acid receptor subunit alpha-1

  • GABA(A) receptor subunit alpha-1

  • gamma-aminobutyric acid (GABA) A receptor, alpha 1

  • gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1

  • gamma-aminobutyric acid A receptor, alpha 1

  • gamma-aminobutyric acid type A receptor alpha1 subunit

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05209 GABRA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gabra1 NCBI NCBI:2554