PLCG1 - phospholipase C gamma 1 Gene

Also Known as PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5335

About PLCG1

Cytogenetic location: 20q12 Genomic coordinates (GRCh38): 20:41,137,543-41,177,626 (from NCBI)

This gene has 23 transcripts (splice variants), 214 orthologues, 14 paralogues and is associated with 78 phenotypes. Ubiquitous expression in endometrium (RPKM 23.5), lymph node (RPKM 23.2) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by Src, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic Fibroblast Growth Factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PLCG1 Products (2)

mRNA	Protein	Name
NM_002660.3	NP_002651.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a
NM_182811.2	NP_877963.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables neurotrophin TRKA receptor binding	IPI IPI: Inferred from physical interaction	15488758	GOA
enables phosphatidylinositol phospholipase C activity	IDA IDA: Inferred from direct assay	2550068	GOA
enables phospholipase C activity	IDA IDA: Inferred from direct assay	20510673	GOA
enables phospholipase C activity	IMP IMP: Inferred from mutant phenotype	37422272	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1396585	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	22454520	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	17229814	GOA
involved in cellular response to epidermal growth factor stimulus	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	20011604	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	20011604	GOA
involved in positive regulation of endothelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	27464494	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	17229814	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	22454520	GOA
involved in positive regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	27464494	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	22561606	GOA
located in cell projection	IDA IDA: Inferred from direct assay	22454520	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15702972	GOA
located in cytosol	IDA IDA: Inferred from direct assay	2550068	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	17229814	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	20510673	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	2550068	GOA
located in ruffle	IDA IDA: Inferred from direct assay	17229814	GOA
is active in ruffle membrane	IDA IDA: Inferred from direct assay	11331309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLCG1 Protein Structure

EF-hand_like

PI-PLC-X

SH2

SH3_1

PI-PLC-Y

0
200
400
600
800
1000
1200
1290 a.a.

Protein Preferred Names	Protein Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	1-phosphatidyl-D-myo-inositol-4,5-bisphosphate

PLCG1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PLCG1	P19174	NTRK1	Homo sapiens	P04629	CoIP	8384556
Intra	PLCG1	P19174	FGFR1	Homo sapiens	P11362	Anti Bait CoIP	8321198
Intra	PLCG1	P19174	FGFR1	Homo sapiens	P11362	Pull Down	1656221
Intra	PLCG1	P19174	FGFR1	Homo sapiens	P11362	BRET	20932831
Intra	PLCG1	P19174	FGFR1	Homo sapiens	P11362	PLA	25241761
Intra	PLCG1	P19174	MET	Homo sapiens	P08581	FPS	24728074
Intra	PLCG1	P19174	ABL2	Homo sapiens	P42684	Fluorescence	17474147
Intra	PLCG1	P19174	LAT	Homo sapiens	O43561	CoIP	9489702
Intra	PLCG1	P19174	LAT	Homo sapiens	O43561	Pull Down	10811803
Intra	PLCG1	P19174	LAT	Homo sapiens	O43561	Anti Bait CoIP	16938345
Intra	PLCG1	P19174	LAT	Homo sapiens	O43561	SPR	24642916
Intra	PLCG1	P19174	KHDRBS1	Homo sapiens	Q07666	Pull Down	7537265
Intra	PLCG1	P19174	KIT	Homo sapiens	P10721	FPS	24728074
Intra	PLCG1	P19174	FGFR2	Homo sapiens	P21802-1	Pull Down	24440983
Intra	PLCG1	P19174	FGFR2	Homo sapiens	P21802-1	Anti Bait CoIP	24440983
Intra	PLCG1	P19174	RIN3	Homo sapiens	Q8TB24	Fluorescence	17474147
Intra	PLCG1	P19174	SHANK2	Homo sapiens	Q9UPX8	Pull Down	17474147
Intra	PLCG1	P19174	SHANK3	Homo sapiens	Q9BYB0	Peptide Array	17474147
Intra	PLCG1	P19174	SNX17	Homo sapiens	Q15036	Fluorescence	17474147
Intra	PLCG1	P19174	DUSP15	Homo sapiens	Q9H1R2	Fluorescence	17474147
Intra	PLCG1	P19174	SCARB1	Homo sapiens	Q8WTV0-3	Pull Down	14570588
Intra	PLCG1	P19174	AKT1	Homo sapiens	P31749	Anti Bait CoIP	16525023
Intra	PLCG1	P19174	EGFR	Homo sapiens	P00533	Pull Down	9020117
Intra	PLCG1	P19174	EGFR	Homo sapiens	P00533	Far-WB	9020117
Intra	PLCG1	P19174	SOS1	Homo sapiens	Q07889	Fluorescence	17474147
Intra	PLCG1	P19174	SOS1	Homo sapiens	Q07889	Pull Down	9020117
Intra	PLCG1	P19174	ASAP2	Homo sapiens	O43150	Fluorescence	17474147
Intra	PLCG1	P19174	ASAP2	Homo sapiens	O43150	Pull Down	17474147
Intra	PLCG1	P19174	ASAP1	Homo sapiens	Q9ULH1	Anti Bait CoIP	17474147
Intra	PLCG1	P19174	GRB2	Homo sapiens	P62993	Pull Down	9020117
Intra	PLCG1	P19174	RAC1	Homo sapiens	P63000	Pull Down	19264842
Intra	PLCG1	P19174	RAC1	Homo sapiens	P63000	Anti Bait CoIP	19264842
Intra	PLCG1	P19174	RAC1	Homo sapiens	P63000	Anti Tag CoIP	19264842
Intra	PLCG1	P19174	INSR	Homo sapiens	P06213	Pull Down	9593725
Intra	PLCG1	P19174	INSR	Homo sapiens	P06213	Crosslink	14568990
Intra	PLCG1	P19174	INSR	Homo sapiens	P06213	Pull Down	11796522
Intra	PLCG1	P19174	INSR	Homo sapiens	P06213	IF	14568990
Intra	PLCG1	P19174	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	PLCG1	P19174	AR	Homo sapiens	P10275	FPS	24728074
Intra	PLCG1	P19174	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	PLCG1	P19174	PDGFRB	Homo sapiens	P09619	CoIP	11896612
Intra	PLCG1	P19174	PDGFRB	Homo sapiens	P09619	NMR	15641795
Intra	PLCG1	P19174	PDGFRB	Homo sapiens	P09619	CoIP	1396585
Intra	PLCG1	P19174	PDGFRB	Homo sapiens	P09619	NMR	23063561
Intra	PLCG1	P19174	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	PLCG1	P19174	FCGR2B	Homo sapiens	P31994	Fluorescence	17474147
Intra	PLCG1	P19174	VIL1	Homo sapiens	P09327	Anti Bait CoIP	16921170
Intra	PLCG1	P19174	CD22	Homo sapiens	P20273	CoIP	8627166
Intra	PLCG1	P19174	SYK	Homo sapiens	P43405	Pull Down	8657103
Intra	PLCG1	P19174	MAP4K1	Homo sapiens	Q92918	Pull Down	17474147
Intra	PLCG1	P19174	MAP4K1	Homo sapiens	Q92918	Anti Bait CoIP	17474147
Intra	PLCG1	P19174	MAP4K1	Homo sapiens	Q92918	Anti Tag CoIP	17474147
Intra	PLCG1	P19174	MAP4K1	Homo sapiens	Q92918	Peptide Array	17474147
Cross	PLCG1	P19174	EEF1A2	Oryctolagus cuniculus	Q71V39	Pull Down	17936057

Cross: Cross-species interaction Intra: Intraspecies interaction

PLCG1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80427	Phospholipase C gamma 1 Antibody (YA179)	WB, ICC/IF, IP	Human
HY-P84153	Phospholipase C gamma 1 Antibody (YA3850)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
HY-P84153A	Phospholipase C gamma 1 Antibody (YA3850)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat, Monkey
HY-P84154	Phospholipase C gamma 1 Antibody (YA3851)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P84154A	Phospholipase C gamma 1 Antibody (YA3851)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
HY-P86178	Phospholipase C gamma 1 Antibody (YA5870)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Paroxysmal Nocturnal Hemoglobinuria	Marchiafava-Micheli Disease Pnh Hemoglobinuria, Paroxysmal Marchiafava-Micheli Syndrome Paroxysmal Hemoglobinuria Nocturnal Nocturnal Haemoglobinuria Nocturnal Paroxysmal Haematuria Nocturnal Paroxysmal Haemoglobinaemia
Tangier Disease	Analphalipoproteinemia High Density Lipoprotein Deficiency, Tangier Type TGD High Density Lipoprotein Deficiency, Type 1 Hdldt1 Familial High Density Lipoprotein Deficiency A-Alphalipoprotein Neuropathy Alpha High Density Lipoprotein Deficiency Disease Cholesterol Thesaurismosis Familial High Density Lipoprotein Deficiency Disease Hdl Lipoprotein Deficiency Disease Tangier Disease Neuropathy Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency 1 Primary Hypoalphalipoproteinemia 1 Analphalipo-Proteinemia Familial Hypoalphalipo-Proteinemia Familial Hypoalphalipoproteinemia Lipoprotein Deficiency Disease, Hdl, Familial Tangier Hereditary Neuropathy Atp-Binding Cassette Transporter A1 Deficiency Hdld1 High Density Lipoprotein Deficiency 1 Tangier Disease, Variant Hypoalphalipoproteinemia, Familial Familial Hdl Deficiency
Mycobacterium Kansasii	Infection Due To Mycobacterium Kansasii
Immunodeficiency 17	IMD17 Cd3-Gamma Deficiency Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive Combined Immunodeficiency Due To Cd3gamma Deficiency Immunodeficiency 17, Cd3 Gamma Deficient Cd3gamma Deficiency Immunodeficiency, Type 17
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	XMEN X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia Cid Due To Magt1 Deficiency Combined Immunodeficiency Due To Magt1 Deficiency X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Hypophosphatasia	Phosphoethanolaminuria Childhood Hypophosphatasia Deficiency Of Alkaline Phosphatase Hypophospatasia, Childhood Hypophosphatasia Mild Phosphoethanol-Aminuria Rathburn Disease Hpp Rathbun Disease Hypophosphatasia, Childhood Infantile Hypophosphatasia
Ovarian Angiosarcoma	Hemangiosarcoma Of Ovary
Skin Angiosarcoma	Angiosarcoma Of Skin Hemangiosarcoma Of The Skin Haemangiosarcoma Of Skin Lymphangiosarcoma Of Skin Cutaneous Angiosarcoma Malignant Haemangioendothelioma Of Skin
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Pfeiffer Syndrome	Infectious Mononucleosis Acs5 Craniofacial-Skeletal-Dermatologic Dysplasia Acs V Noack Syndrome Gammaherpesviral Mononucleosis Acrocephalosyndactyly Type 5 Pfeiffer Syndrome Type 3 Acrocephalosyndactyly, Type V Glandular Fever Pfeiffer Type Acrocephalosyndactyly Pfeiffer Syndrome Type 2 Acrocephalosyndactylia Type V Filatov'S Disease Monocytic Angina Mononucleosis Pfeiffer'S Disease Acsv Acrocephalosyndactyly, Type 5 Craniofacial-Skeletal-Dermatologic Syndrome Pfeiffer Syndrome Type 1 Classic Pfeiffer Syndrome PS Pfeiffer Syndrome Variant Dysplasia, Craniofacial-Skeletal-Dermatologic Pfeiffer Kissing Disease Infectious Adenitis Pfeiffer Disease
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
T-Cell Adult Acute Lymphocytic Leukemia	Acute Adult T-Cell Leukemia-Lymphoma Adult Precursor T Lymphoblastic Leukemia Atll T-Cell Adult Acute Lymphoblastic Leukemia
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Angioimmunoblastic T-Cell Lymphoma	Immunoblastic Lymphadenopathy Lymphogranulomatosis X T-Cell Lymphoma, Aild Type Aitl Ailt Angioimmunoblastic Lymphadenopathy Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia] Angioimmunoblastic Lymphoma
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS10660	PLCG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19470	Plcg1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25963	Plcg1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLCG1	VGNC	VGNC:76169
Canis familiaris	PLCG1	VGNC	VGNC:44651
Rattus norvegicus	PLCG1	RGD	RGD:3347
Felis catus	PLCG1	VGNC	VGNC:82452
Bos taurus	PLCG1	VGNC	VGNC:32988
Mus musculus	PLCG1	MGD	MGI:97615
Others	PLCG1	NCBI