SNX17 - sorting nexin 17 Gene

Homo sapiens

Gene ID: 9784 | Gene type: protein coding

About SNX17

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,370,616-27,377,535 (from NCBI)

This gene has 10 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 29.0), lymph node (RPKM 26.3) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-Selectin, and may function in the intracellular trafficking of P-Selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

SNX17 Products(4)

mRNA	Protein	Name
NM_001267059.2	NP_001253988.1	sorting nexin-17 isoform 2
NM_001267060.2	NP_001253989.1	sorting nexin-17 isoform 3
NM_001267061.2	NP_001253990.1	sorting nexin-17 isoform 4
NM_014748.4	NP_055563.1	sorting nexin-17 isoform 1

SNX17 Protein Structure

0
100
200
300
400
470 a.a.

Protein Preferred Names

Protein Names

sorting nexin-17

Related Diseases

Diseases

Alias

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13530	SNX17 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNX17	RGD	RGD:1306424
Mus musculus	SNX17	MGD	MGI:2387801
Macaca mulatta	SNX17	VGNC	VGNC:77709
Bos taurus	SNX17	VGNC	VGNC:35097
Canis familiaris	SNX17	VGNC	VGNC:46626
Felis catus	SNX17	VGNC	VGNC:65547

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