DUSP15 - dual specificity phosphatase 15 Gene

Also Known as VHY; C20orf57

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 128853

About DUSP15

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:31,845,593-31,870,664 (from NCBI)

This gene has 10 transcripts (splice variants), 109 orthologues and 30 paralogues. Biased expression in testis (RPKM 10.5), kidney (RPKM 3.2) and 1 other tissue.

Summary

The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific Phosphatase activity, and therefore is known as a dual specificity Phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

DUSP15 Products (5)

mRNA	Protein	Name
NM_001012644.3	NP_001012662.1	dual specificity protein phosphatase 15 isoform b
NM_001320478.1	NP_001307407.1	dual specificity protein phosphatase 15 isoform c
NM_001320479.1	NP_001307408.1	dual specificity protein phosphatase 15 isoform d
NM_080611.5	NP_542178.2	dual specificity protein phosphatase 15 isoform a
NM_177991.3	NP_817130.1	dual specificity protein phosphatase 15 isoform b

DUSP15 Protein Structure

DSPc

0
100
200
295 a.a.

Protein Preferred Names	Protein Names
dual specificity protein phosphatase 15	VH1-related member Y

DUSP15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DUSP15	Q9H1R2	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	DUSP15	Q9H1R2	PLCG1	Homo sapiens	P19174	Peptide Array	17474147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nanophthalmos	Nanophthalmia
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04056	DUSP15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DUSP15	VGNC	VGNC:50028
Canis familiaris	DUSP15	VGNC	VGNC:103673
Mus musculus	DUSP15	MGD	MGI:1934928
Felis catus	DUSP15	VGNC	VGNC:61663
Rattus norvegicus	DUSP15	RGD	RGD:1305990
Macaca mulatta	DUSP15	VGNC	VGNC:71848
Others	DUSP15	NCBI