GRP78-IN-2
GRP78-IN-2 (Compound FL5) is a GRP78 (Glucose Regulated Protein 78 kDa) inhibitor. GRP78-IN-2 preferentially targeting cell surface GRP78 and shows potent antiangiogenic and anticancer activities without affecting other normal cells.
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- CAS No.: 1882875-63-9
- Formule: C29H29NO6
- Masse moléculaire:487.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
|
Grp78 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 786-0 | CC50 |
10 μM
Compound: FL5
|
Cytotoxicity against human 786-0 cells assessed reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human 786-0 cells assessed reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 32199134] |
| HUVEC | CC50 |
10 μM
Compound: FL5
|
Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32199134] |
| HUVEC | EC50 |
1.514 μM
Compound: FL5
|
Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay
Antiangiogenic activity against VEGF-stimulated HUVEC assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 32199134] |
Chemical Information
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CAS No. 1882875-63-9
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Masse moléculaire 487.54
-
Formule C29H29NO6
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SMILES
COC1=CC(OC)=CC(C(OCC2=CC=C(C=C2)C3=C(C4=CC=CC=C4O3)C(NCC(C)C)=O)=O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)