HPK1-IN-56
HPK1-IN-56 (Compound A29) is a HPK1 inhibitor (IC50: 2.70 nM). HPK1-IN-56 inhibits downstream p-SLP76 (IC50: 8.1 nM in Jurkat T cells). HPK1-IN-56 induces the production of IL-2 in human PBMCs. HPK1-IN-56 has anticancer effect, enhances T-cell killing ability and the antitumor efficacy of anti-PD-1 antibody.
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- CAS No.: 2901054-39-3
- Formule: C24H26N8O
- Masse moléculaire:442.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Voir tous les produits spécifiques à Isoform MAP4K
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Activité biologique
|
HPK1 2.7 nM (IC50) |
MAP4K4 18.2 nM (IC50) |
MAP4K6 27.9 nM (IC50) |
MAP4K5 79.1 nM (IC50) |
GLK/MAP4K3 29.2 nM (IC50) |
MAP4K2 104.3 nM (IC50) |
Chemical Information
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CAS No. 2901054-39-3
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Masse moléculaire 442.52
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Formule C24H26N8O
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SMILES
COC1=C(NC2=NN=C3C(N)=CC(C4=C(C)C(N)=CN=C4)=CC3=N2)C=C5CN(C)CCC5=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPK1-IN-56 Related Classifications
HY-172107 Related Classifications
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