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Cat. No.: HY-174208

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KLHDC2-IN-1

KLHDC2-IN-1 (Compound 6) is a ligand targeting the ubiquitin E3 ligase KLHDC2 (K_d: 160 nM). KLHDC2-IN-1 enables the synthesis of a PROTAC that can effectively degrade BRD4 in cells.

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CAS No.: 1005275-19-3
Formule: C₂₂H₁₉ClF₃NO₃
Masse moléculaire:437.84

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

KLHDC2-IN-1 Chemical Structure

CAS No.: 1005275-19-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

KLHDC2-IN-1 (Compound 6) is a ligand targeting the ubiquitin E3 ligase KLHDC2 (K_d: 160 nM). KLHDC2-IN-1 enables the synthesis of a PROTAC that can effectively degrade BRD4 in cells^[1].

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Chemical Information

CAS No. 1005275-19-3
Masse moléculaire 437.84
Formule C₂₂H₁₉ClF₃NO₃
SMILES

OC(C1=C2C(C(C3CCC4C3)C4C(C5=CC(OC(F)(F)F)=CC=C5)N2)=CC(Cl)=C1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhou H, et al. Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening[J]. eLife, 2025, 14: RP106844.

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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KLHDC2-IN-1

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase