Lamotrigine hydrate
Based on 7 publication(s) in Google Scholar
Lamotrigine hydrate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine hydrate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine hydrate can be used for the research of epilepsy, focal seizure, et al.
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- CAS No.: 375347-20-9
- Formule: C9H9Cl2N5O
- Masse moléculaire:274.11
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Lamotrigine hydrate
More- Nat Chem Biol. 2025 Jun 2. [Abstract]
- Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2309773120. [Abstract]
- JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]
- Cell Calcium. 2022 Mar:102:102527. [Abstract]
- Pharmacol Res Perspect. 2021 Oct;9(5):e00879. [Abstract]
- Pharmacol Res Perspect. 2020 Apr;8(2):e00575. [Abstract]
- Pharmacol Biochem Behav. 2018 May:168:43-50. [Abstract]
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Cell Proliferation/Viability Assay
Activité biologique
Lamotrigine hydrate inhibits Veratrine evoked release of glutamate and aspartate with ED50 values of 21 μM for both amino acids, but Lamotrigine hydrate is less potent in the inhibition of GABA release (ED50=44 μM. At concentrations up to 300 μM, LTG has no effect on patassium-evoked amino acid[1]. Lamotrigine hydrate is some five times less potent in the inhibition of Veratrine-evoked [3H]acetylcholine release (ED50=100 μM) than in glutamate or aspartate release[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 375347-20-9
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Masse moléculaire 274.11
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Formule C9H9Cl2N5O
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SMILES
NC1=NC(N)=C(C2=CC=CC(Cl)=C2Cl)N=N1.O
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Synonyms
LTG hydrate; BW430C hydrate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Nat Chem Biol
2025 Jun 2. PMID: 40456963 -
Proc Natl Acad Sci U S A
2023 Oct 10;120(41):e2309773120. PMID: 37782796 -
JCI Insight
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice. [Abstract]2022 Aug 8;7(15):e160247. PMID: 35938532
Lamotrigine hydrate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]
Mice were administered Lamotrigine (20 mg/kg) or vehicle 1 hour before PTZ injections. Pretreatment with the positive control Lamotrigine (LTG) significantly decreased the severity of acute seizures.
Lamotrigine hydrate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]
Mice were administered Lamotrigine (20 mg/kg) or vehicle 1 hour before PTZ injections. Mice in the Lamotrigine group showed a delayed response to PTZ.
Lamotrigine hydrate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]
Examples of daily recordings of spontaneous recurrent seizures in the vehicle, Lamotrigine, APAP and APAP/17AAG treatment groups. Lamotrigine was administered i.p. at a dose of 20 mg/kg daily.
Lamotrigine hydrate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]
The intrahippocampal injection of KA reliably models refractory TLE with HS and the model mice displayed drug-resistant characteristics after repeated administration of Lamotrigine.
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Cell Calcium
Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer. [Abstract]2022 Mar:102:102527. PMID: 35026540
Lamotrigine hydrate purchased from MedChemExpress. Usage Cited in: Cell Calcium. 2022 Mar:102:102527. [Abstract]
The cells were treated with Lamotrigine (0-150 μM) at indicated concentrations for 48 h and analyzed by CCK-8 Cell Counting assay.
Lamotrigine hydrate purchased from MedChemExpress. Usage Cited in: Cell Calcium. 2022 Mar:102:102527. [Abstract]
Effects of Lamotrigine (0-25 μM) on colony forming activity of H1299 and H1975 cells.
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Pharmacol Res Perspect
Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. [Abstract]2021 Oct;9(5):e00879. PMID: 34628723 -
Pharmacol Res Perspect
Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats. [Abstract]2020 Apr;8(2):e00575. PMID: 32266794 -
Pharmacol Biochem Behav
Anticonvulsants lamotrigine and riluzole disrupt maternal behavior in postpartum female rats. [Abstract]2018 May:168:43-50. PMID: 29572014
Pureté et documentation
Références
[1]. M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27(5):490-7. [Content Brief]
[2]. Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv). Apr-Jun 2011;53(2):57-62. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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