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Lamotrigine isethionate

(別名: LTG isethionate; BW430C isethionate)
7 Cited Publications
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Based on 7 publication(s) in Google Scholar

Lamotrigine (BW430C) isethionate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine isethionate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine isethionate can be used for the research of epilepsy, focal seizure, et al.

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  • CAS 番号: 113170-86-8
  • 分子式: C11H13Cl2N5O4S
  • 分子量:382.22
  • 保管条件:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Lamotrigine isethionate Chemical Structure
    Lamotrigine isethionate 構造式
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
CAS 番号: 113170-86-8
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  • Lamotrigine isethionate Chemical Structure
    Lamotrigine isethionate Chemical Structure
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  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]

    Customer Validation
     Mice were administered Lamotrigine (20 mg/kg) or vehicle 1 hour before PTZ injections. Pretreatment with the positive control Lamotrigine (LTG) significantly decreased the severity of acute seizures.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]

    Customer Validation
     Mice were administered Lamotrigine (20 mg/kg) or vehicle 1 hour before PTZ injections. Mice in the Lamotrigine group showed a delayed response to PTZ.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]

    Customer Validation
     Examples of daily recordings of spontaneous recurrent seizures in the vehicle, Lamotrigine, APAP and APAP/17AAG treatment groups. Lamotrigine was administered i.p. at a dose of 20 mg/kg daily.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]

    Customer Validation
     The intrahippocampal injection of KA reliably models refractory TLE with HS and the model mice displayed drug-resistant characteristics after repeated administration of Lamotrigine.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: Cell Calcium. 2022 Mar:102:102527. [Abstract]

    Customer Validation
     The cells were treated with Lamotrigine (0-150 μM) at indicated concentrations for 48 h and analyzed by CCK-8 Cell Counting assay.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: Cell Calcium. 2022 Mar:102:102527. [Abstract]

    Customer Validation
     Effects of Lamotrigine (0-25 μM) on colony forming activity of H1299 and H1975 cells.

  • Lamotrigine isethionate