2. Membrane Transporter/Ion Channel Autophagy
  3. Sodium Channel Autophagy
  4. Lamotrigine isethionate

Lamotrigine isethionate  (Synonyms: LTG isethionate; BW430C isethionate)

Cat. No.: HY-110032
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Lamotrigine (BW430C) isethionate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine isethionate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine isethionate can be used for the research of epilepsy, focal seizure, et al.

For research use only. We do not sell to patients.

CAS No. : 113170-86-8

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Customer Review

Based on 7 publication(s) in Google Scholar

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Lamotrigine isethionate Related Antibodies

Top Publications Citing Use of Products

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247.  [Abstract]

    Mice were administered Lamotrigine (20 mg/kg) or vehicle 1 hour before PTZ injections. Pretreatment with the positive control Lamotrigine (LTG) significantly decreased the severity of acute seizures.

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247.  [Abstract]

    Mice were administered Lamotrigine (20 mg/kg) or vehicle 1 hour before PTZ injections. Mice in the Lamotrigine group showed a delayed response to PTZ.

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247.  [Abstract]

    Examples of daily recordings of spontaneous recurrent seizures in the vehicle, Lamotrigine, APAP and APAP/17AAG treatment groups. Lamotrigine was administered i.p. at a dose of 20 mg/kg daily.

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247.  [Abstract]

    The intrahippocampal injection of KA reliably models refractory TLE with HS and the model mice displayed drug-resistant characteristics after repeated administration of Lamotrigine.

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: Cell Calcium. 2022 Mar:102:102527.

    The cells were treated with Lamotrigine (0-150 μM) at indicated concentrations for 48 h and analyzed by CCK-8 Cell Counting assay.

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: Cell Calcium. 2022 Mar:102:102527.

    Effects of Lamotrigine (0-25 μM) on colony forming activity of H1299 and H1975 cells.

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    Description

    Lamotrigine (BW430C) isethionate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine isethionate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine isethionate can be used for the research of epilepsy, focal seizure, et al[1][2].

    Clinical Trial
    Molecular Weight

    382.22

    Formula

    C11H13Cl2N5O4S
    CAS No.
    Appearance

    No data available

    SMILES

    O=S(O)(CCO)=O.ClC1=C(Cl)C(C2=C(N)N=C(N)N=N2)=CC=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Purity & Documentation
    References
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    Lamotrigine isethionate Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lamotrigine113170-86-8LTGBW430CSodium ChannelAutophagyNa channelsNa+ channelsInhibitorinhibitorinhibit

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