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Lamotrigine isethionate

(Synonyms: LTG isethionate; BW430C isethionate)
7 Cited Publications
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Based on 7 publication(s) in Google Scholar

Lamotrigine (BW430C) isethionate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine isethionate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine isethionate can be used for the research of epilepsy, focal seizure, et al.

For research use only. We do not sell to patients.

  • CAS No.: 113170-86-8
  • Formula: C11H13Cl2N5O4S
  • Molecular Weight:382.22
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Lamotrigine isethionate Chemical Structure
    Lamotrigine isethionate Chemical Structure
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
  • Experimental Validation Results for Lamotrigine isethionate
CAS No.: 113170-86-8
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  • Lamotrigine isethionate Chemical Structure
    Lamotrigine isethionate Chemical Structure
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    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]

    Customer Validation
     Mice were administered Lamotrigine (20 mg/kg) or vehicle 1 hour before PTZ injections. Pretreatment with the positive control Lamotrigine (LTG) significantly decreased the severity of acute seizures.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]

    Customer Validation
     Mice were administered Lamotrigine (20 mg/kg) or vehicle 1 hour before PTZ injections. Mice in the Lamotrigine group showed a delayed response to PTZ.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]

    Customer Validation
     Examples of daily recordings of spontaneous recurrent seizures in the vehicle, Lamotrigine, APAP and APAP/17AAG treatment groups. Lamotrigine was administered i.p. at a dose of 20 mg/kg daily.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Aug 8;7(15):e160247. [Abstract]

    Customer Validation
     The intrahippocampal injection of KA reliably models refractory TLE with HS and the model mice displayed drug-resistant characteristics after repeated administration of Lamotrigine.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: Cell Calcium. 2022 Mar:102:102527. [Abstract]

    Customer Validation
     The cells were treated with Lamotrigine (0-150 μM) at indicated concentrations for 48 h and analyzed by CCK-8 Cell Counting assay.

  • 1/16

    Lamotrigine isethionate purchased from MedChemExpress. Usage Cited in: Cell Calcium. 2022 Mar:102:102527. [Abstract]

    Customer Validation
     Effects of Lamotrigine (0-25 μM) on colony forming activity of H1299 and H1975 cells.

  • Lamotrigine isethionate