Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
selectins
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "selectins" in MCE Product Catalog:
12
12 Publications Verification
Cat. No.: HY-N0250
CAS No.: 20874-52-6
Category:
Infection Triterpenes Terpenoids Plants Umbelliferae Disease Research Fields Inflammation/Immunology Carphephorus corymbosus (Nutt.) Torr. & A.Gray
Target:
9
9 Cited Publications
Synonyms: P-Selectin Inhibitor
Target:
Domaines de recherche:
PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM .
5
5 Cited Publications
Target:
Domaines de recherche:
A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases .
5
Domaines de recherche:
Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM . Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo .
4
Target:
Domaines de recherche:
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects .
4
4 Cited Publications
Cat. No.: HY-U00003
CAS No.: 251994-14-6
Target:
Domaines de recherche:
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC50 values of 7 and 5 nM, respectively.
2
2 Cited Publications
Cat. No.: HY-160109
Target:
Domaines de recherche:
Ac5GalNTGc is a potent, peracetylated C-2 thioglycolyl-substituted GalNAc analog that efficiently inhibits mucin-type O-glycan biosynthesis. Ac5GalNTGc reduces leukocyte sialyl-Lewis-X expression and inhibits L-/P-selectin mediated rolling under flow, as well as P-selectin dependent leukocyte-platelet adhesion. Ac5GalNTGc exhibits anti-inflammatory activity in a thioglycollate-induced acute peritonitis model. Ac5GalNTGc can be used for studies of O-glycan/mucin biology, inflammation, and related translational research .
2
2 Cited Publications
Target:
Domaines de recherche:
KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM .
1
Target:
Domaines de recherche:
Edelfosine (ET-18-OCH3) is an orally active lipid raft modulator and apoptosis inducer that alters membrane fluidity and preferentially inserts into tumor cell membranes. Edelfosine recruits death receptor ligands (FasL/CD95L, TRAIL) and Bid to lipid rafts to form death-inducing signaling complexes, thereby initiating mitochondria-dependent apoptosis and inducing cytochrome c release. Edelfosine also exerts anti-inflammatory effects, promotes L-Selectin shedding, and causes no gastrointestinal or organ toxicity. In addition, Edelfosine inhibits nucleic acid and protein synthesis in Leishmania donovani and exhibits antiproliferative activity. Edelfosine can be used in research on multiple myeloma, inflammatory bowel diseases (such as ulcerative colitis and Crohn's disease), and visceral leishmaniasis .
1
Target:
Domaines de recherche:
1
Category:
Polysaccharides Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides
Target:
1
1 Cited Publications
Cat. No.: HY-P99263
CAS No.: 1256258-86-2
Synonyms: Anti-Human selectin P Recombinant Antibody
Target:
Domaines de recherche:
1
1 Cited Publications
Cat. No.: HY-P990247
Target:
Domaines de recherche:
1
1 Cited Publications
Cat. No.: HY-N0620
CAS No.: 102841-43-0
1
Target:
Domaines de recherche:
Sialyl Lewis A (SLeA) sodium is a tumor-associated carbohydrate antigen, also known as carbohydrate antigen 19-9 (CA19-9), that binds to E-selectin (ELAM-1) and selectins to mediate cell-endothelium adhesion. Sialyl Lewis A sodium promotes cancer cell-vascular endothelium adhesion, and its surface presence correlates with increased tumorigenicity and invasiveness in cancer cells. Sialyl Lewis A sodium shows elevated expression in human adenocarcinomas of the colon, pancreas, and stomach, with expression levels linked to tumor progression and poor prognosis in colorectal and gastric carcinomas. Sialyl Lewis A sodium can be used for the research of cancers, such as colon, pancreas, stomach, and squamous lung cancer .
1
1 Cited Publications
Synonyms: 6-Desoxygalactose (Standard); L-(-)-Fucose (Standard); L-Galactomethylose (Standard)
Category:
Human Gut Microbiota Metabolites Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Monosaccharides
Target:
Cat. No.: HY-132828
CAS No.: 1639303-73-3
Synonyms: LT3001; DHDMIQK(KAP)
Target:
Domaines de recherche:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Cat. No.: HY-125475
CAS No.: 927881-99-0
Synonyms: GMI-1070
Target:
Domaines de recherche:
Rivipansel is a small-molecule glycomimetic pan-selectin antagonist with inhibitory activity against E-selectin and P-selectin. Rivipansel binds tightly to the lectin domain of E-selectin, and selectively blocks the recognition of CD62L by E-selectin without affecting the binding of PSGL-1 to E-selectin. Rivipansel functionally inhibits the adhesion of hematopoietic cells to endothelial cells, and is applicable to research related to sickle cell disease .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
