TAT-PiET
TAT-PiET is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET can reduce BRD4 and JMJD6 levels and inhibit cell proliferation. TAT-PiET also resists the endocrine resistance of ERα-positive breast cancer cells. TAT-PiET can be used for the research of cancer, such as breast cancer.
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- CAS No.: 3036046-03-1
- Formule: C110H192N48O27S
- Masse moléculaire:2651.07
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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BRD4 |
TAT-PiET inhibits proliferation in MCF7, T47D, MDA-MB231, and BT549 cell with EC50 values of 8.13, 13.35, 4.68 and 32.34 μM[1].
TAT-PiET (10 μM) inhibits colony formations in MCF7 and MDA-MB231 cells
TAT-PiET (10 μM) inhibits migration in MCF7 and MDA-MB231 cells
TAT-PiET (10 μM, 6 h) decreases expression of c-Myc, N-myc, and CCND1 in MCF7 and MDA-MB-231 cells
TAT-PiET (10 μM) increases sensitivities in Tamoxifen (HY-13757A) -resistant MCF7 and T47Dcells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 and MDA-MB-231 cells
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Concentration:10 μM
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Incubation Time:6 h
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Result:Decreased expression of c-Myc, N-myc, and CCND1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MCF7/MDA-MB231 tumor mice models[1]
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Dosage:25 mg/kg
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Administration:Intraperitoneally injection, every 2 days
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Result:Reduced tumor volume and weight.
Reduced BRD4 and JMJD6 levels.
Reduced c-Myc, N-myc, and CCND1 levels.
Chemical Information
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CAS No. 3036046-03-1
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Masse moléculaire 2651.07
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Formule C110H192N48O27S
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Sequence
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Asn-Gln-Lys-Phe-Lys-Cys-Gly-Glu
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Sequence Shortening
YGRKKRRQRRRRNQKFKCGE
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TAT-PiET Related Classifications
HY-P10445 Related Classifications
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