1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Caroverine hydrochloride

Caroverine hydrochloride 

Cat. No.: HY-106467B Purity: 96.56%
Handling Instructions

Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus.

For research use only. We do not sell to patients.

Caroverine hydrochloride Chemical Structure

Caroverine hydrochloride Chemical Structure

CAS No. : 55750-05-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 165 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 480 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Caroverine hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus[1][2][3].

IC50 & Target

NMDA[1]
AMPA[1]

In Vitro

Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure[4]
Dosage: 1.44 mg/rat
Administration: 20 mg/mL; s.c. 1.0 mL/h for 72 h
Result: Significantly protected the cochlea against impulse noise trauma.
Molecular Weight

401.93

Formula

C₂₂H₂₈ClN₃O₂

CAS No.
SMILES

O=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4880 mL 12.4400 mL 24.8800 mL
5 mM 0.4976 mL 2.4880 mL 4.9760 mL
10 mM 0.2488 mL 1.2440 mL 2.4880 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CaroverineiGluRIonotropic glutamate receptorsNMDAAMPAglutamateantioxidantcalciumvasorelaxantinnereartinnitusInhibitorinhibitorinhibit

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Product Name:
Caroverine hydrochloride
Cat. No.:
HY-106467B
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