2953730-35-1
Chemical Structure
BCRP-IN-2
- CAS No.: 2953730-35-1
- Formula:C19H13N7
- Molecular Weight:339.35
InChIKey: RKCAPAXYHIXQLP-UHFFFAOYSA-N
SMILES: [N-]=[N+]=NC1=CC=C(NC2=NC(C3=CC=NC=C3)=NC4=CC=CC=C42)C=C1
Biological Activity: BCRP-IN-2 has BCRP inhibitory activity and shows even greater inhibition of BCRP after activation by ultraviolet light. BCRP-IN-2 can be a valuable probe for studying the interactions of quinazolinamine derivatives with BCRP, as it stimulates ATP hydrolysis of the BCRP transport protein, increasing the accumulation of mitoxantrone (HY-13502) in H460/MX20 cells with BCRP overexpression[1].
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BCRP-IN-2 | BCRP-IN-2 has BCRP inhibitory activity and shows even greater inhibition of BCRP after activation by ultraviolet light. BCRP-IN-2 can be a valuable probe for studying the interactions of quinazolinamine derivatives with BCRP, as it stimulates ATP hydrolysis of the BCRP transport protein, increasing the accumulation of mitoxantrone (HY-13502) in H460/MX20 cells with BCRP overexpression. | |||||||||||||||||||||
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Keywords
