3964-81-6
3964-81-6
Chemical Structure
Azatadine
- CAS No.: 3964-81-6
- Formula:C20H22N2
- Molecular Weight:290.40
IUPAC Name: 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
InChIKey: SEBMTIQKRHYNIT-UHFFFAOYSA-N
SMILES: CN1CC/C(CC1)=C2C3=CC=CC=C3CCC4=CC=CN=C4\2
Biological Activity: Azatadine is an orally active histamine H1 receptor inhibitor, cetylcholine receptor inhibitor, and serotonin receptor inhibitor. Azatadine induces sedation and exhibits topical anesthetic properties. Azatadine can be used for the research of allergic rhinitis[1][2][3].
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Azatadine | Azatadine is an orally active histamine H1 receptor inhibitor, cetylcholine receptor inhibitor, and serotonin receptor inhibitor. Azatadine induces sedation and exhibits topical anesthetic properties. Azatadine can be used for the research of allergic rhinitis. | |||||||||||||||||||||
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References
- [1]. Tozzi S, et al. The pharmacology of azatadine, a potential antiallergy drug. Agents Actions. 1974 Oct;4(4):264-70. [Content Brief]
- [2]. Katelaris C, et al. Comparative effects of loratadine and azatadine in the treatment of seasonal allergic rhinitis. Asian Pac J Allergy Immunol. 1990;8(2):103-107. [Content Brief]
- [3]. Togias AG, et al. Demonstration of inhibition of mediator release from human mast cells by azatadine base. In vivo and in vitro evaluation. JAMA. 1986 Jan 10;255(2):225-9. [Content Brief]
Keywords
