477-30-5
Chemical Structure
Demecolcine
Synonym(s): Colcemid
- CAS No.: 477-30-5
- Formula:C21H25NO5
- Molecular Weight:371.43
IUPAC Name: (S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
InChIKey: NNJPGOLRFBJNIW-HNNXBMFYSA-N
SMILES: O=C1C=C2[C@@H](NC)CCC3=CC(OC)=C(OC)C(OC)=C3C2=CC=C1OC
Biological Activity: Demecolcine is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Demecolcine | 99.81% | Demecolcine is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research. | ||||||||||||||||||||
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Demecolcine (Standard) | 99.84% | Demecolcine (Standard) (Colcemid (Standard)) is the analytical standard of Demecolcine (HY-N0282). This product is intended for research and analytical applications. Demecolcine (Colcemid) is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Demecolcine can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Demecolcine can be used for inflammatory disorders and cancer research. | ||||||||||||||||||||
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- [1]. T Tsuchida, et al. Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle. Cytometry. 1998 Apr 1;31(4):295-9. [Content Brief]
- [2]. Ashley M Rozario, et al. Ultra-Low Colcemid Doses Induce Microtubule Dysfunction as Revealed by Super-Resolution Microscopy. Bioexiv.
Keywords
