492-00-2
Chemical Structure
3,7-Dihydroxyflavone
Synonym(s): Resogalangin
- CAS No.: 492-00-2
- Formula:C15H10O4
- Molecular Weight:254.24
IUPAC Name: 3,7-dihydroxy-2-phenyl-4H-chromen-4-one
InChIKey: UWQJWDYDYIJWKY-UHFFFAOYSA-N
SMILES: O=C1C(O)=C(C2=CC=CC=C2)OC3=CC(O)=CC=C13
Biological Activity: 3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3,7-Dihydroxyflavone | 98.04% | 3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm. | ||||||||||||||||||||
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- [1]. Ma J, et al. Spectroscopic investigation on the interaction of 3,7-dihydroxyflavone with different isomers of human serum albumin. Food Chem. 2012 May 1;132(1):663-70. [Content Brief]
- [2]. Neves MP, et al. Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis. Eur J Med Chem. 2011 Jun;46(6):2562-74. [Content Brief]
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