60-80-0
60-80-0
Chemical Structure
Antipyrine
Synonym(s): Phenazone; Phenazon
- CAS No.: 60-80-0
- Formula:C11H12N2O
- Molecular Weight:188.23
IUPAC Name: 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
InChIKey: VEQOALNAAJBPNY-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC=CC=C2)N(C)C(C)=C1
Biological Activity: Antipyrine (Phenazone) is an orally active antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine also delays gastric emptying (GE) in rats[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Antipyrine | 99.93% | Antipyrine (Phenazone) is an orally active antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine also delays gastric emptying (GE) in rats. | ||||||||||||||||||||
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Antipyrine (Standard) | 99.99% | Antipyrine (Standard) is the analytical standard of Antipyrine. This product is intended for research and analytical applications. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity. | ||||||||||||||||||||
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Antipyrine-d3 | 99.91% | Antipyrine-d3 is the deuterium labeled Antipyrine. Antipyrine (Phenazone) is an antipyretic and analgesic. Antipyrine can be used as a probe agent for oxidative agent metabolism. Antipyrine has been widely used in assessment of hepatic oxidative capacity. | ||||||||||||||||||||
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Iodoantipyrine | 98.0% | Iodoantipyrine (4-Iodoantipyrine) is an iodinated Antipyrine (HY-B0171) with potential antiviral activity. Antipyrine (Phenazone) is an antipyretic and analgesic that also serves as a molecular probe of hepatic oxidative metabolites. | ||||||||||||||||||||
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Iodoantipyrine (Standard) | ≥98% | Iodoantipyrine (Standard) is the analytical standard of Iodoantipyrine. This product is intended for research and analytical applications. Iodoantipyrine (4-Iodoantipyrine) is an iodinated Antipyrine (HY-B0171) with potential antiviral activity. Antipyrine (Phenazone) is an antipyretic and analgesic that also serves as a molecular probe of hepatic oxidative metabolites. | ||||||||||||||||||||
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Antileishmanial agent-31 | Antileishmanial agent-31 (Compound p1) is a pyrazole derivative. Antileishmanial agent-31 has anti-leishmania activity with an IC50 of 35.53 μg/mL. In addition, Antileishmanial agent-31 has high stability. Antileishmanial agent-31 can be used for anti-leishmaniasis research. | |||||||||||||||||||||
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5-Chloro-4-formyl-3-methyl-1-phenylpyrazole | 99.93% | 5-Chloro-4-formyl-3-methyl-1-phenylpyrazole is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Ampyrone | 99.72% | Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy. | ||||||||||||||||||||
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Ampyrone (Standard) | 99.23% | Ampyrone (4-Aminophenazone) (Standard) is the analytical standard of Ampyrone (HY-B1398). This product is intended for research and analytical applications. Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy. | ||||||||||||||||||||
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Ampyrone-d3 | Ampyrone-d3 is the deuterium labeled Ampyrone (HY-B1398). Ampyrone (4-Aminophenazone; 4-Aminoantipyrine) is a reversible and low-damage optical clearing agent and non-selective COX inhibitor based on UV absorption properties. Ampyrone can improve the optical transmittance of mouse skin and other tissues. Ampyrone can induce tissue refractive index matching by enhancing UV absorption, reduce light scattering, and achieve tissue transparency in vivo. Ampyrone reduces the synthesis of prostaglandin PGE2, thereby exerting anti-inflammatory, analgesic and antipyretic effects. Ampyrone inhibits DNA damage, cell apoptosis and immune cell phagocytosis induced by Doxorubicin (HY-15142A) and Cisplatin (HY-17394), etc., and participates in the regulation of toxicity in tumor chemotherapy. | |||||||||||||||||||||
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4-Hydroxyantipyrine | 99.9% | 4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain. | ||||||||||||||||||||
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4-Hydroxyantipyrine (Standard) | ≥98% | 4-Hydroxyantipyrine (Standard) is the analytical standard of 4-Hydroxyantipyrine. This product is intended for research and analytical applications. 4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain. | ||||||||||||||||||||
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4-Hydroxyantipyrine-d3 | 4-Hydroxyantipyrine-d3 is the deuterium labeled 4-Hydroxyantipyrine. 4-Hydroxyantipyrine is the major metabolite of Antipyrine, can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Antipyrine in the brain. | |||||||||||||||||||||
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1,2-Dimethylindole | 99.68% | 1,2-Dimethylindole is an indole derivative. 1,2-Dimethylindole involves cytochrome P450-mediated oxidative reactions (e.g., hydroxylation, oxidative demethylation). 1,2-Dimethylindole is promising for research of antitumor agents and enzyme inhibitors. | ||||||||||||||||||||
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5-Bromo-1-methyl-1H-indazole-d3 | 5-Bromo-1-methyl-1H-indazole-d3 is the deuterium labeled 5-Bromo-1-methyl-1H-indazole. | |||||||||||||||||||||
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5-Bromo-2-methyl-2H-indazole-d3 | 5-Bromo-2-methyl-2H-indazole-d3 is the deuterium labeled 5-Bromo-2-methyl-2H-indazole. | |||||||||||||||||||||
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Terilitin impurity 17 | 99.92% | Terilitin impurity 17 is an impurity of Terilitin. | ||||||||||||||||||||
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References
- [1]. Stevenson, I.H., Factors influencing antipyrine elimination. Br J Clin Pharmacol, 1977. 4(3): p. 261-5. [Content Brief]
- [2]. Engel G, et, al. Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. Clin Pharmacol Ther. 1996 Jun;59(6):613-23. [Content Brief]
- [3]. RENKIN EM. Capillary and cellular permeability to some compounds related to antipyrine. Am J Physiol. 1953 Apr;173(1):125-30. [Content Brief]
- [4]. Soares AC, et al. Effect of antipyrine on the gastric emptying of liquid in rats. Braz J Med Biol Res. 2006 Nov;39(11):1507-12. [Content Brief]
