667-65-2
Chemical Structure
Beta-Cortol
- CAS No.: 667-65-2
- Formula:C21H36O5
- Molecular Weight:368.51
IUPAC Name: (3R,5R,8S,9S,10S,11S,13S,14S,17R)-17-((R)-1,2-dihydroxyethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,11,17-triol
InChIKey: FFPUNPBUZDTHJI-ZFOKFBPFSA-N
SMILES: C[C@]1(C[C@@H]2O)[C@](CC[C@]1(O)[C@H](O)CO)([H])[C@@]3([H])[C@@]2([H])[C@](CC[C@@H](O)C4)(C)[C@]4([H])CC3
Biological Activity: Beta-Cortol is an O-glycosylated compound and cortisol metabolite. It can be isolated from the leaves of mulberry cultivar Yu 711, and its concentration decreases significantly when the plant is subjected to drought stress. Beta-Cortol serves as a biomarker, as serum Beta-Cortol levels in early non-small cell lung cancer models are downregulated to 1/8 of the preoperative level after tumor resection. Due to such dramatic changes under specific pathological conditions, Beta-Cortol is currently widely used in studies related to early non-small cell lung cancer[1][2].
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Beta-Cortol | 99.9% | Beta-Cortol is an O-glycosylated compound and cortisol metabolite. It can be isolated from the leaves of mulberry cultivar Yu 711, and its concentration decreases significantly when the plant is subjected to drought stress. Beta-Cortol serves as a biomarker, as serum Beta-Cortol levels in early non-small cell lung cancer models are downregulated to 1/8 of the preoperative level after tumor resection. Due to such dramatic changes under specific pathological conditions, Beta-Cortol is currently widely used in studies related to early non-small cell lung cancer. | ||||||||||||||||||||
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- [1]. Ahmed N, et al. Metabolic Changes in Early-Stage Non-Small Cell Lung Cancer Patients after Surgical Resection. Cancers (Basel). 2021;13(12):3012. Published 2021 Jun 16. [Content Brief]
- [2]. Ackah M, et al. Metabolomics response to drought stress in Morus alba L. variety Yu-711[J]. Plants, 2021, 10(8): 1636.
Keywords
