81-23-2
Chemical Structure
Dehydrocholic acid
Synonym(s): Dehydrocholate
- CAS No.: 81-23-2
- Formula:C24H34O5
- Molecular Weight:402.52
IUPAC Name: (R)-4-((5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7,12-trioxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
InChIKey: OHXPGWPVLFPUSM-KLRNGDHRSA-N
SMILES: C[C@H](CCC(O)=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])C(C[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC2=O)=O)=O
Biological Activity: Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice[1][2][3][4][5].
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Dehydrocholic acid | 99.92% | Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice. | ||||||||||||||||||||
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Dehydrocholic acid (Standard) | ≥98% | Dehydrocholic acid (Dehydrocholate) (Standard) is the analytical standard of Dehydrocholic acid (HY-B1393). This product is intended for research and analytical applications. Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice. | ||||||||||||||||||||
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Similarity Score 0.90
HY-B0998Dehydrocholic acid sodium -
Similarity Score 0.85
HY-413257,12-Diketolithocholic acid -
Similarity Score 0.84
HY-W749329(5β)-3,12-Dioxocholan-24-oic acid -
Similarity Score 0.84
HY-W747313Dehydrochenodeoxycholic acid -
Similarity Score 0.77
HY-W1275865β-Cholanic acid 3,7-dione methyl ester -
Similarity Score 0.75
HY-168760(5α)-3,6-Dioxocholan-24-oic acid -
Similarity Score 0.75
HY-1777955β-Cholanic acid-3,6-dione -
Similarity Score 0.74
HY-135772R12-Ketodeoxycholic acid (Standard) -
Similarity Score 0.74
HY-125801R3-Oxo-5β-cholanoic acid (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Zhang X, et al. Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice. Biol Pharm Bull. 2020;43(6):985-993. [Content Brief]
- [2]. Yousef IM, et al. Influence of dehydrocholic acid on the secretion of bile acids and biliary lipids in rats. Digestion. 1990;45(1):40-51. [Content Brief]
- [3]. Ratan J, et al. A controlled trial of choleretic and hepatoprotective actions of Livzon and dehydrocholic acid in a model of obstructive jaundice in albino rats. Tohoku J Exp Med. 1997 Jan;181(1):161-6. [Content Brief]
- [4]. UCHIDA K, et al. EFFECTS OF SODIUM URSODEOXYCHOLATE, HYODEOXY-CHOLATE AND DEHYDROCHOLATE ON CHOLESTEROL AND BILE ACID METABOLISM IN RATS. Journal of Pharmacobio-Dynamics, 1983, 6(5): 346-357.
- [5]. Magos L, et al. The effect of phenobarbital and sodium dehydrocholate on the biliary excretion of methylmercury in the rat. Toxicology and Applied Pharmacology, 1974, 30(1): 1-6.
