Art. -Nr.: HY-N3686

D-Arabitol

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D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research.

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Reinheit: 99.92%
CAS. Nr.: 488-82-4
Formel: C₅H₁₂O₅
Molecular Weight:152.15

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

D-Arabitol Chemical Structure

CAS. Nr.: 488-82-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Alle AMPK Isoform-spezifische Produkte anzeigen :

In Vitro

D-arabitol (10-60 mM; duration of growth phase) supports growth of Bacillus methanolicus MGA3 as a sole carbon source with a growth rate of 0.20 h⁻¹ at 15 mM, and is co-consumed with mannitol in equimolar mixtures^[2].
D-arabitol (15 mM; growth to mid-exponential phase, OD₆₀₀ = 1.0) induces significant upregulation of the atlABCD gene cluster in Bacillus methanolicus MGA3, with atlD transcript levels also elevated in co-consumption conditions with mannitol^[2].
D-arabitol (30 mM; duration of growth phase) allows heterologous expression of Bacillus methanolicus MGA3 atlD alone, or the full atlABCD gene cluster, to restore growth of arabitol-negative Corynebacterium glutamicum ΔmtlD^[2].
D-arabitol (15 mM; growth to mid-exponential phase, OD₆₀₀ = 1.0) induces elevated arabitol phosphate dehydrogenase activity (0.05 U/mg) in crude cell extracts of Bacillus methanolicus MGA3, with high affinity for xylulose 5-phosphate (K_m = 0.03 mM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[2]

Cell Line:

Bacillus methanolicus MGA3
Concentration:

15 mM (RNA-seq, sole carbon source); 15 mM (RNA-seq, mannitol control); 15 mM (qRT-PCR, D-arabitol plus 15 mM mannitol)
Incubation Time:

growth to mid-exponential phase (OD₆₀₀ = 1.0)
Result:

Induced significant upregulation of the atlA (log2 fold change = 3.06), atlB (log2 fold change = 3.41), atlC (log2 fold change = 2.73), and atlD (log2 fold change = 2.90) gene cluster when used as a 15 mM sole carbon source compared to 15 mM mannitol.
Showed elevated atlD transcript levels in cells grown on 15 mM D-arabitol plus 15 mM mannitol compared to mannitol alone, as confirmed by qRT-PCR.

In Vivo

D-Arabitol (4-8%; dietary supplement; daily administration; 10 weeks) dose-dependently improves high-fat diet (HFD)-induced obesity, insulin resistance, lipid deposition and inflammation in male SD rats. Its mechanism of action involves regulating the gut microbiota, increasing SCFA production, and promoting white adipose tissue (WAT) browning via the AMPK-PGC-1α pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (SD) (male, 180 g)^[1]
Dosage:

4% (dietary supplementation); 8% (dietary supplementation)
Administration:

dietary supplementation; daily; 10 weeks
Result:

Significantly reduced HFD-induced body weight gain, liver weight, epididymal fat weight, and Lee's index, with 8% D-Arabitol showing a greater reduction than 4%.
Reduced HFD-induced fasting glucose by 28.17% (8% dose).
Significantly decreased the HOMA-IR index and increased the QUICK index and serum adiponectin levels (both doses).
Dose-dependently reduced serum total cholesterol (TC), triacylglycerols (TG), low-density lipoprotein cholesterol (LDL-C), and hepatic TC and TG, while increasing serum high-density lipoprotein cholesterol (HDL-C) and reducing serum leptin, with 8% D-Arabitol showing more significant lipid-lowering effects than 4%.
Significantly reduced HFD-increased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, and reduced hepatic lipid droplet accumulation (8% dose).
Dose-dependently reduced serum levels of proinflammatory cytokines C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and decreased relative mRNA expression of proinflammatory cytokines IL-6, TNF-α, interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) in epididymal adipose tissue, while increasing anti-inflammatory cytokine interleukin-10 (IL-10) mRNA expression (both doses).
Significantly increased fecal concentrations of propionic acid, butyric acid, isovaleric acid, and total short-chain fatty acids (SCFAs) compared to the HFD group (8% dose).
Upregulated relative mRNA expression of white adipose tissue (WAT) browning-related genes PPAR-γ, Cidea, Prdm16, PGC-1α, and UCP-1 in epididymal adipose tissue, and increased protein expression of AMPK, p-AMPK, and PPAR-γ (8% dose).

Chemical Information

CAS. Nr. 488-82-4
Appearance Solid
Molecular Weight 152.15
Formel C₅H₁₂O₅
Color White to off-white
SMILES

OCC(O)C(O)C(O)CO
Structure Classification
- Saccharides
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 66.67 mg/mL (438.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.5725 mL

32.8623 mL

65.7246 mL

5 mM

1.3145 mL

6.5725 mL

13.1449 mL

10 mM

0.6572 mL

3.2862 mL

6.5725 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (16.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (16.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (16.43 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li X, et al. d-Arabitol Ameliorates Obesity and Metabolic Disorders via the Gut Microbiota-SCFAs-WAT Browning Axis. J Agric Food Chem. 2023;71(1):522-534. [Content Brief]

[2]. López MG, et al. Characterization of D-Arabitol as Newly Discovered Carbon Source of Bacillus methanolicus. Front Microbiol. 2019 Jul 31;10:1725.
[Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.5725 mL	32.8623 mL	65.7246 mL	164.3115 mL
	5 mM	1.3145 mL	6.5725 mL	13.1449 mL	32.8623 mL
	10 mM	0.6572 mL	3.2862 mL	6.5725 mL	16.4312 mL
	15 mM	0.4382 mL	2.1908 mL	4.3816 mL	10.9541 mL
	20 mM	0.3286 mL	1.6431 mL	3.2862 mL	8.2156 mL
	25 mM	0.2629 mL	1.3145 mL	2.6290 mL	6.5725 mL
	30 mM	0.2191 mL	1.0954 mL	2.1908 mL	5.4771 mL
	40 mM	0.1643 mL	0.8216 mL	1.6431 mL	4.1078 mL
	50 mM	0.1314 mL	0.6572 mL	1.3145 mL	3.2862 mL
	60 mM	0.1095 mL	0.5477 mL	1.0954 mL	2.7385 mL
	80 mM	0.0822 mL	0.4108 mL	0.8216 mL	2.0539 mL
	100 mM	0.0657 mL	0.3286 mL	0.6572 mL	1.6431 mL

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D-Arabitol

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Alle AMPK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

D-Arabitol Related Classifications

HY-N3686 Related Classifications