Art. -Nr.: HY-W016887

Glycyl-L-proline

(Synonyms: H-Gly-Pro-OH; Gly-Pro)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Glycyl-L-proline (H-Gly-Pro-OH) is a dipeptide. Glycyl-L-proline can induce MCF-7 cells apoptosis. Glycyl-L-proline can enhance the inhibitory effect of the PRODH/POX knockout on collagen and DNA biosynthesis. Glycyl-L-proline can inhibit Gly-Sar and L-proline transport. Glycyl-L-proline can be used for the researches of cancer and metabolic disease, such as breast cancer.

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Reinheit: 99.88%
CAS. Nr.: 704-15-4
Formel: C₇H₁₂N₂O₃
Molecular Weight:172.18

Speicherung:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Glycyl-L-proline Chemical Structure

CAS. Nr.: 704-15-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	EC₅₀	0.13 mM Compound: 36	Activation of human PEPT1 expressed in MDCK cells Activation of human PEPT1 expressed in MDCK cells	[PMID: 16759105]
MDCK	IC₅₀	0.33 mM Compound: 36	Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells	[PMID: 16759105]

In Vitro

Glycyl-L-proline (17,22 μg/ml; 24 h) does not significantly affect cell viability in MCF-7 and MCF-7shPRODH/POX (knocked-down PRODH/POX) cells^[1].
Glycyl-L-proline (17,22 μg/ml; 24 h) induces apoptosis in MCF-7 cells^[1].
Glycyl-L-proline (17,22 μg/ml; 24 h) decreases collagen biosynthesis and DNA biosynthesis in MCF-7shPRODH/POX^[1].
Glycyl-L-proline (10-50000 μM; 10 mins) decreases intracellular Gly-Sar uptake in Caco-2 cells with an IC₅₀ of 257 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7 and MCF-7shPRODH/POX
Concentration:

17,22 μg/ml
Incubation Time:

24 h
Result:

Showed no significant difference in cell viability between MCF-7 shPRODH/POX and MCF-7 control cells.

Western Blot Analysis^[1]

Cell Line:

MCF-7 and MCF-7shPRODH/POX
Concentration:

17,22 μg/ml
Incubation Time:

24 h
Result:

Decreased the expression of PRODH/POX, p53, Caspase 9 in MCF-7 cells.
Increased Caspase 3, cleaved Caspase 3, cleaved Caspase 9, iNOS, NF-κB, COX-2 and AMPKβ levels in MCF-7 cells.
Increased Caspase 9 levles in MCF-7shPRODH/POX cells.

Chemical Information

CAS. Nr. 704-15-4
Appearance Solid
Molecular Weight 172.18
Formel C₇H₁₂N₂O₃
Color White to off-white
Synonyms

H-Gly-Pro-OH; Gly-Pro
Structure Classification
- Alkaloids
- Pyrrole Alkaloids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Redox Biol

ReDisulphID: A discovery platform for thiol redox sensors identifies a druggable site regulating p53 activation. [Abstract]

2026 Jul:94:104196. PMID: 42097034

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 20 mg/mL (116.16 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1 mg/mL (5.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.8079 mL

29.0394 mL

58.0788 mL

5 mM

1.1616 mL

5.8079 mL

11.6158 mL

10 mM

0.5808 mL

2.9039 mL

5.8079 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zareba I, et al. Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. Oncotarget. 2018;9(17):13748-13757. Published 2018 Feb 9. [Content Brief]

[2]. von Linde T, et al. Rapid and Sensitive Quantification of Intracellular Glycyl-Sarcosine for Semi-High-Throughput Screening for Inhibitors of PEPT-1. Pharmaceutics. 2021;13(7):1019. Published 2021 Jul 3. [Content Brief]

[3]. Boyd CA, et al. L-proline transport by brush border membrane vesicles prepared from human placenta. J Physiol. 1981;315:9-19. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	5.8079 mL	29.0394 mL	58.0788 mL	145.1969 mL
DMSO / H₂O	5 mM	1.1616 mL	5.8079 mL	11.6158 mL	29.0394 mL
H₂O	10 mM	0.5808 mL	2.9039 mL	5.8079 mL	14.5197 mL
	15 mM	0.3872 mL	1.9360 mL	3.8719 mL	9.6798 mL
	20 mM	0.2904 mL	1.4520 mL	2.9039 mL	7.2598 mL
	25 mM	0.2323 mL	1.1616 mL	2.3232 mL	5.8079 mL
	30 mM	0.1936 mL	0.9680 mL	1.9360 mL	4.8399 mL
	40 mM	0.1452 mL	0.7260 mL	1.4520 mL	3.6299 mL
	50 mM	0.1162 mL	0.5808 mL	1.1616 mL	2.9039 mL
	60 mM	0.0968 mL	0.4840 mL	0.9680 mL	2.4199 mL
	80 mM	0.0726 mL	0.3630 mL	0.7260 mL	1.8150 mL
	100 mM	0.0581 mL	0.2904 mL	0.5808 mL	1.4520 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Glycyl-L-proline

1 Cited Publications

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Glycyl-L-proline

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Publications Citing Use of MedChemExpress (MCE) Glycyl-L-proline

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Glycyl-L-proline Related Classifications

HY-W016887 Related Classifications