Bleomycin B2 sulfate
Based on 1 Customer Validation
Bleomycin B2 (Phleomycin D2) sulfate is a selective antitumor and antibacterial agent that induces DNA strand breaks and inhibits DNA ligase activity. The optimal pH for the activity of Bleomycin B2 sulfate is 9.1, and its efficacy is enhanced by thiol compounds or hydrogen peroxide. Bleomycin B2 sulfate undergoes enzymatic inactivation via bleomycin-inactivating enzymes, exhibits selective retention in squamous cell carcinoma, and is inactivated most rapidly in liver and kidney homogenates. Bleomycin B2 sulfate can be applied in research related to squamous cell carcinoma and other relevant studies.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.96%
- CAS. Nr.: 51773-86-5
- Formel: C55H86N20O25S3
- Molecular Weight:1523.59
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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DNA Ligase |
Bleomycin B2 sulfate (1000 μg/mL; 30 min) undergoes the fastest inactivation in mouse liver and kidney homogenates, with only 6.8% and 5.0% of activity remaining, respectively; whereas its inactivation is the slowest in mouse lung and skin homogenates, with 40.2% and 34.2% of activity remaining, respectively[1].
Bleomycin B2 sulfate (100 μg/mL; 60 min) is potently inactivated by partially purified mouse liver bleomycin-inactivating enzyme at 37°C; complete inactivation is achieved after 60 min when the enzyme concentration is ≥1 mg protein[1].
The inactivation activity of Bleomycin B2 sulfate by the enzyme protein extracted from mouse sarcoma tissues induced by 20-methylcholanthrene is significantly higher than that by the enzyme protein extracted from mouse squamous cell carcinoma tissues induced by 20-methylcholanthrene (mean 32.71 units/g vs mean 14.45 units/g)[1].
Bleomycin B2 sulfate (0.1-40 μg/mL; 2-60 min) induces single-strand breaks in supercoiled SV40 DNA in a cell-free system, and its activity is increased 20-fold in the presence of 1 mM 2-mercaptoethanol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 51773-86-5
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Appearance Solid
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Molecular Weight 1523.59
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Formel C55H86N20O25S3
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Color White to off-white
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SMILES
O=S(O)(O)=O.O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@@H]([C@H](O)C)C(NCCC2=NC(C3=NC(C(NCCCCNC(N)=N)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@@H]6[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O
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Synonyms
Phleomycin D2 sulfate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (65.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6563 mL | 3.2817 mL | 6.5634 mL | 16.4086 mL |
| 5 mM | 0.1313 mL | 0.6563 mL | 1.3127 mL | 3.2817 mL | |
| 10 mM | 0.0656 mL | 0.3282 mL | 0.6563 mL | 1.6409 mL | |
| 15 mM | 0.0438 mL | 0.2188 mL | 0.4376 mL | 1.0939 mL | |
| 20 mM | 0.0328 mL | 0.1641 mL | 0.3282 mL | 0.8204 mL | |
| 25 mM | 0.0263 mL | 0.1313 mL | 0.2625 mL | 0.6563 mL | |
| 30 mM | 0.0219 mL | 0.1094 mL | 0.2188 mL | 0.5470 mL | |
| 40 mM | 0.0164 mL | 0.0820 mL | 0.1641 mL | 0.4102 mL | |
| 50 mM | 0.0131 mL | 0.0656 mL | 0.1313 mL | 0.3282 mL | |
| 60 mM | 0.0109 mL | 0.0547 mL | 0.1094 mL | 0.2735 mL |
Bleomycin B2 sulfate Related Classifications
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