51773-86-5
Chemical Structure
Bleomycin B2 sulfate
Synonym(s): Phleomycin D2 sulfate
- CAS No.: 51773-86-5
- Formula:C55H86N20O25S3
- Molecular Weight:1523.59
InChIKey: CIRWIMDKXPKOMA-WEJIAYKGSA-N
SMILES: O=S(O)(O)=O.O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@@H]([C@H](O)C)C(NCCC2=NC(C3=NC(C(NCCCCNC(N)=N)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@@H]6[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O
Biological Activity: Bleomycin B2 (Phleomycin D2) sulfate is a selective antitumor and antibacterial agent that induces DNA strand breaks and inhibits DNA ligase activity. The optimal pH for the activity of Bleomycin B2 sulfate is 9.1, and its efficacy is enhanced by thiol compounds or hydrogen peroxide. Bleomycin B2 sulfate undergoes enzymatic inactivation via bleomycin-inactivating enzymes, exhibits selective retention in squamous cell carcinoma, and is inactivated most rapidly in liver and kidney homogenates. Bleomycin B2 sulfate can be applied in research related to squamous cell carcinoma and other relevant studies[1][2].
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Bleomycin B2 sulfate | 99.96% | Bleomycin B2 (Phleomycin D2) sulfate is a selective antitumor and antibacterial agent that induces DNA strand breaks and inhibits DNA ligase activity. The optimal pH for the activity of Bleomycin B2 sulfate is 9.1, and its efficacy is enhanced by thiol compounds or hydrogen peroxide. Bleomycin B2 sulfate undergoes enzymatic inactivation via bleomycin-inactivating enzymes, exhibits selective retention in squamous cell carcinoma, and is inactivated most rapidly in liver and kidney homogenates. Bleomycin B2 sulfate can be applied in research related to squamous cell carcinoma and other relevant studies. | ||||||||||||||||||||
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- [1]. UMEZAWA H, et al. Studies on the mechanism of antitumor effect of bleomycin on squamous cell carcinoma[J]. The Journal of Antibiotics, 1972, 25(7): 409-420.
- [2]. UMEZAWA H, et al. The effect of bleomycin on SV40 DNA: Characteristics of bleomycin action which produces a single scission in a superhelical form of SV40 DNA[J]. The Journal of Antibiotics, 1973, 26(9): 521-527.
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