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Art. -Nr.: HY-161991

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Caspase-3 activator 4

Caspase-3 activator 4 (compound 4o) is a potent and cross the blood-brain barrier caspase-3 activator. Caspase-3 activator 4 shows antiproliferative activity. Caspase-3 activator 4 induces apoptosis. Caspase-3 activator 4 increases the gene expression of TNF-α. Caspase-3 activator 4 decreases the protein expression of cleaved caspases 3/caspases 3.

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CAS. Nr.: 1817874-62-6
Formel: C₃₁H₂₇N₅O₃
Molecular Weight:517.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Caspase-3 activator 4 Chemical Structure

CAS. Nr.: 1817874-62-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
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Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Caspase 3

Alle Caspase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
LN-229	IC₅₀	>100 μM Compound: Pseudellone C	Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 68 hrs by CCK-8 assay Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 68 hrs by CCK-8 assay	[PMID: 39213937]
U-87MG ATCC	IC₅₀	168.2 μM Compound: Pseudellone C	Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth incubated for 68 hrs by CCK-8 assay Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell growth incubated for 68 hrs by CCK-8 assay	[PMID: 39213937]

Chemical Information

CAS. Nr. 1817874-62-6
Molecular Weight 517.58
Formel C₃₁H₂₇N₅O₃
SMILES

CC(C(N[C@@H](C(C1=CNC2=C1C=CC=C2)=O)C(NC)=O)=O)(C3=CNC4=C3C=CC=C4)C5=CNC6=C5C=CC=C6
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Qin X, Xu W, Hu J, Dong Y, Ding R, Huang S, Zhao Z, Chang H, Wang X, Dong S. Structure-activity relationship study of Pseudellone C as anti-glioma agents by targeting TNF/TNFR signaling pathway. Eur J Med Chem. 2024 Aug 26;278:116799. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
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Caspase-3 activator 4

Alle Caspase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Caspase-3 activator 4 Related Classifications

HY-161991 Related Classifications