(E/Z)-HA155
Based on 1 Customer Validation
(E/Z)-HA155 is a potent autotaxin (ATX) type I inhibitor. (E/Z)-HA155 can be used for researching cancer, fibrotic diseases, inflammation, pain and angiogenesis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.58%
- CAS. Nr.: 1229652-22-5
- Formel: C24H19BFNO5S
- Molecular Weight:463.29
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Covalent Screening Library
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Neurodegenerative Disease-related Compound Library
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Anti-Colorectal Cancer Compound Library
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Heterocyclic Compound Library
HY-L138
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Metabolic Enzyme Compound Library
HY-L146
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Boronic Acid Compound Library
HY-L167
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
Biologische Aktivität
Autotaxin[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
5.67 nM
Compound: 73
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Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as lysophosphatidulcholine release
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[PMID: 20536182] |
| HEK293 | IC50 |
5.7 nM
Compound: 1, HA155
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Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as choline release using lysophosphatidylcholine as substrate after 4 hrs by choline release assay
Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells assessed as choline release using lysophosphatidylcholine as substrate after 4 hrs by choline release assay
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[PMID: 21615078] |
Chemical Information
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CAS. Nr. 1229652-22-5
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Appearance Solid
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Molecular Weight 463.29
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Formel C24H19BFNO5S
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Color Off-white to light yellow
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SMILES
OB(O)C1=CC=C(C=C1)COC2=CC=C(C=C2)/C=C(C3=O)\SC(N3CC4=CC=C(C=C4)F)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (269.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1585 mL | 10.7924 mL | 21.5848 mL | 53.9619 mL |
| 5 mM | 0.4317 mL | 2.1585 mL | 4.3170 mL | 10.7924 mL | |
| 10 mM | 0.2158 mL | 1.0792 mL | 2.1585 mL | 5.3962 mL | |
| 15 mM | 0.1439 mL | 0.7195 mL | 1.4390 mL | 3.5975 mL | |
| 20 mM | 0.1079 mL | 0.5396 mL | 1.0792 mL | 2.6981 mL | |
| 25 mM | 0.0863 mL | 0.4317 mL | 0.8634 mL | 2.1585 mL | |
| 30 mM | 0.0719 mL | 0.3597 mL | 0.7195 mL | 1.7987 mL | |
| 40 mM | 0.0540 mL | 0.2698 mL | 0.5396 mL | 1.3490 mL | |
| 50 mM | 0.0432 mL | 0.2158 mL | 0.4317 mL | 1.0792 mL | |
| 60 mM | 0.0360 mL | 0.1799 mL | 0.3597 mL | 0.8994 mL | |
| 80 mM | 0.0270 mL | 0.1349 mL | 0.2698 mL | 0.6745 mL | |
| 100 mM | 0.0216 mL | 0.1079 mL | 0.2158 mL | 0.5396 mL |
(E/Z)-HA155 Related Classifications
HY-116100 Related Classifications
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