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Emavusertib mesylate

(Synonyms: CA-4948 mesylate)
7 Cited Publications
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Based on 7 publication(s) in Google Scholar

Emavusertib mesylate (CA-4948 mesylate) is the mesylate salt form of Emavusertib (HY-135317). Emavusertib mesylate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib mesylate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib mesylate exhibits antitumor activity in mouse model.

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  • CAS. Nr.: 2376399-40-3
  • Formel: C25H29N7O8S
  • Molecular Weight:587.60
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Emavusertib mesylate Chemical Structure
    Emavusertib mesylate Chemical Structure
  • Experimental Validation Results for Emavusertib mesylate
  • Experimental Validation Results for Emavusertib mesylate
  • Experimental Validation Results for Emavusertib mesylate
  • Experimental Validation Results for Emavusertib mesylate
  • Experimental Validation Results for Emavusertib mesylate
  • Experimental Validation Results for Emavusertib mesylate
CAS. Nr.: 2376399-40-3
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  • Emavusertib mesylate Chemical Structure
    Emavusertib mesylate Chemical Structure
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    Emavusertib mesylate purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Sep;39(9):2163-2173. [Abstract]

    Customer Validation
     Cell viability was determined in THP1 and HL60 cells cultured with 10 µM CA-4948 (Emavusertib) or in OCI-AML3 and K562 cultured with 1 µM CA-4948 or vehicle (n = 4) for 14 days and then treated with CC-885 (n = 4).

  • 1/16

    Emavusertib mesylate purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Sep;39(9):2163-2173. [Abstract]

    Customer Validation
     Immunoblots for c-MYC in the patient-derived AML samples (AML1794, AML1714) cultured with CA-4948 (Emavusertib) (10 µM) or vehicle for 14 days and then treated with CC-885 (50 nM) for 4 h.

  • 1/16

    Emavusertib mesylate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 24;44(10):116347. [Abstract]

    Customer Validation
     Harvested tumor weights by treatment condition (n = 8 per condition).Tumor growth studies demonstrated statistically significant inhibition with both CA-4948 (Emavusertib) (50 mg/kg; oral gavage; once daily) alone and ICB alone.

  • 1/16

    Emavusertib mesylate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Sep 24;44(10):116347. [Abstract]

    Customer Validation
     H&E and trichrome staining of tumors by treatment condition (Emavusertib (50 mg/kg; oral gavage; once daily), ect.) at 10× magnification. The scale bar represents 100 μm.

  • 1/16

    Emavusertib mesylate purchased from MedChemExpress. Usage Cited in: Blood. 2023 Sep 14;142(11):989-1007. [Abstract]

    Customer Validation
     IC50 curves for CA-4948 (Emavusertib) (0.01-10000 nM; 24 h) and PF-06650833 in an assay measuring NF-kB activity upon TLR2 stimulation with PAM3CSK4 in THP1 NF-kB reporter cells.

  • 1/16

    Emavusertib mesylate purchased from MedChemExpress. Usage Cited in: Blood. 2023 Sep 14;142(11):989-1007. [Abstract]

    Customer Validation
     Immunoblots for phospho-IRAK1, total IRAK1, IRAK2, and IRAK4 in MDSL and AML (1714) treated for 24 hours with CA-4948 (Emavusertib) (10 μM). The results showed that treatment with CA-4948 resulted in increased IRAK1 phosphorylation.

  • Emavusertib mesylate