Ank1 - ankyrin 1, erythroid Gene

Also Known as nb; pale; Ank-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11733

Summary

Predicted to enable several functions, including enzyme binding activity; spectrin binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including erythrocyte development; iron ion homeostasis; and porphyrin-containing compound biosynthetic process. Located in cortical cytoskeleton; membrane; and spectrin-associated Cytoskeleton. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; retina; and skeletal muscle. Used to study hereditary spherocytosis type 1 and malaria. Human ortholog(s) of this gene implicated in anemia; hereditary spherocytosis; and hereditary spherocytosis type 1. Orthologous to human ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Apr 2022]

Ank1 Products (9)

mRNA Protein Name
NM_001110783.3 NP_001104253.1 ankyrin-1 isoform 1
NM_001277280.2 NP_001264209.1 ankyrin-1 isoform 3
NM_001277281.2 NP_001264210.1 ankyrin-1 isoform 4
NM_001277284.2 NP_001264213.1 ankyrin-1 isoform 5
NM_001277286.2 NP_001264215.1 ankyrin-1 isoform 6
NM_001277289.2 NP_001264218.1 ankyrin-1 isoform 7
NM_001310436.1 NP_001297365.1 ankyrin-1 isoform 8 precursor
NM_001310437.1 NP_001297366.1 ankyrin-1 isoform 9 precursor
NM_031158.4 NP_112435.2 ankyrin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17715300 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within erythrocyte development IMP
IMP: Inferred from mutant phenotype
2139228 MGI
acts upstream of or within inorganic cation transmembrane transport IMP
IMP: Inferred from mutant phenotype
7492791 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
23390527 MGI
acts upstream of or within porphyrin-containing compound biosynthetic process IMP
IMP: Inferred from mutant phenotype
658175 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
18723693 MGI
located in membrane IDA
IDA: Inferred from direct assay
18723693 MGI
located in spectrin-associated cytoskeleton IMP
IMP: Inferred from mutant phenotype
6234993 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ankyrin-1

  • erythrocyte ankyrin

  • normoblastic anemia

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00735 ANKS1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00699 ANK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00736 ANKS1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ank1 NCBI NCBI:286