Chuk - conserved helix-loop-helix ubiquitous kinase Gene

Also Known as IKK1; Ikka; Chuk1; Fbx24; IKBKA; Fbxo24; NFKBIKA; IKK alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12675

About Chuk

Chromosome 19: 44,061,774-44,095,919 reverse strand.GRCm39:CM001012.3

This gene has 8 transcripts (splice variants), 266 orthologues, 3 paralogues and is associated with 112 phenotypes. Ubiquitous expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 11.6) and 28 other tissues.

Summary

Enables protein kinase activity. Involved in positive regulation of interferon-alpha production; protein phosphorylation; and response to virus. Acts upstream of or within several processes, including mammary gland development; osteoclast differentiation; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb. Used to study fetal encasement syndrome. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate Cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Apr 2022]

Chuk Products (2)

mRNA Protein Name
NM_007700.2 NP_031726.2 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1
NM_001162410.1 NP_001155882.1 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2

Chuk Protein Structure

STKc_IKK_alpha

STKc_IKK_alpha: cd14039 (20 - 308)

Ubl_IKKA_like

Ubl_IKKA_like: cd17046 (310 - 386)

IKBKB_SDD

IKBKB_SDD: pfam18397 (385 - 658)

IKKbetaNEMObind

IKKbetaNEMObind: pfam12179 (706 - 742)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
Protein Preferred Names Protein Names

inhibitor of nuclear factor kappa-B kinase subunit alpha

  • I kappa B kinase 1

  • I-kappa-B kinase alpha

  • IkappaB kinase alpha

  • nuclear factor NF-kappa-B inhibitor kinase alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02698 CHUK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02699 Chuk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02700 Chuk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chuk NCBI NCBI:1147