SBNO2 - strawberry notch homolog 2 Gene

Also Known as SNO; STNO; KIAA0963

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22904

About SBNO2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,107,638-1,174,268 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 215 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 17.5), spleen (RPKM 13.1) and 25 other tissues.

Summary

Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including cellular response to interleukin-6; macrophage activation involved in immune response; and negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SBNO2 Products (2)

mRNA Protein Name
NM_001100122.2 NP_001093592.1 protein strawberry notch homolog 2 isoform 2
NM_014963.3 NP_055778.2 protein strawberry notch homolog 2 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to interleukin-6 IDA
IDA: Inferred from direct assay
25903009 GOA
involved in macrophage activation involved in immune response IMP
IMP: Inferred from mutant phenotype
18025162 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18025162 GOA
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
18025162 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SBNO2 Protein Structure

AAA_34

AAA_34: P-loop containing NTP hydrolase pore-1 (214 - 505)

Helicase_C_4

Helicase_C_4: C-terminal domain on Strawberry notch homologue (732 - 1010)

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  • 1366 a.a.
Protein Preferred Names Protein Names

protein strawberry notch homolog 2

Related Diseases

Diseases Alias
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12470 SBNO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SBNO2 VGNC VGNC:45885
Rattus norvegicus SBNO2 RGD RGD:1307194
Felis catus SBNO2 VGNC VGNC:82408
Mus musculus SBNO2 MGD MGI:2448490
Macaca mulatta SBNO2 VGNC VGNC:77123
Bos taurus SBNO2 VGNC VGNC:34309
Others SBNO2 NCBI