SUSD4 - sushi domain containing 4 Gene

Also Known as PRO222

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55061

About SUSD4

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,220,831-223,365,235 (from NCBI)

This gene has 17 transcripts (splice variants), 145 orthologues and 39 paralogues. Biased expression in esophagus (RPKM 11.1), ovary (RPKM 10.5) and 13 other tissues.

Summary

Involved in negative regulation of complement activation, alternative pathway and negative regulation of complement activation, classical pathway. Predicted to be located in extracellular region. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SUSD4 Products (3)

mRNA Protein Name
NM_001037175.3 NP_001032252.1 sushi domain-containing protein 4 isoform b precursor
NM_001410929.1 NP_001397858.1 sushi domain-containing protein 4 isoform c
NM_017982.4 NP_060452.3 sushi domain-containing protein 4 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of complement activation, alternative pathway IDA
IDA: Inferred from direct assay
23482636 GOA
involved in negative regulation of complement activation, classical pathway IDA
IDA: Inferred from direct assay
23482636 GOA
involved in regulation of complement activation IDA
IDA: Inferred from direct assay
23482636 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUSD4 Protein Structure

Sushi

Sushi: Sushi repeat (SCR repeat) (57 - 104)

Sushi

Sushi: Sushi repeat (SCR repeat) (122 - 177)

Sushi

Sushi: Sushi repeat (SCR repeat) (180 - 237)

Sushi

Sushi: Sushi repeat (SCR repeat) (243 - 297)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 490 a.a.
Protein Preferred Names Protein Names

sushi domain-containing protein 4

  • YHGM196

Recombinant SUSD4 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P77217 SUSD4 Protein, Human (HEK293, Fc) Q5VX71-3 (F42-F290) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chromosome 1q41-Q42 Deletion Syndrome

  • 1q41-Q42 Microdeletion Syndrome

  • 1q41q42 Microdeletion Syndrome

  • Holoprosencephaly 10, Included

  • Hpe10, Included

  • 1q41-Q42 Deletion Syndrome

  • Deletion 1q41-Q42

  • Monosomy 1q41-Q42

  • Del(1)(Q41q42)

  • Monosomy 1q41q42

  • Chromosome Deletion Syndrome 1q41-Q42

  • Holoprosencephaly 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14049 SUSD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20109 Susd4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26613 Susd4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SUSD4 MGD MGI:2138351
Felis catus SUSD4 VGNC VGNC:65855
Bos taurus SUSD4 VGNC VGNC:35489
Canis familiaris SUSD4 VGNC VGNC:49817
Rattus norvegicus SUSD4 RGD RGD:1564043
Macaca mulatta SUSD4 VGNC VGNC:78211
Others SUSD4 NCBI