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WNT8A - Wnt family member 8A Gene

Also Known as WNT8D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7478

About WNT8A

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,077,367-138,092,365 (from NCBI)

This gene has 4 transcripts (splice variants), 275 orthologues and 18 paralogues. Low expression observed in reference dataset.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

WNT8A Products (3)

mRNA	Protein	Name
NM_001300938.2	NP_001287867.1	protein Wnt-8a isoform 1 precursor
NM_001300939.2	NP_001287868.1	protein Wnt-8a isoform 2 precursor
NM_058244.4	NP_490645.1	protein Wnt-8a isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables receptor ligand activity	IDA IDA: Inferred from direct assay	28733458	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	28733458	GOA
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	18413325	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT8A Protein Structure

wnt

0
100
200
300
351 a.a.

Protein Preferred Names	Protein Names
protein Wnt-8a	WNT8d

Related Diseases

Diseases	Alias
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS15842	WNT8A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WNT8A	RGD	RGD:1306312
Macaca mulatta	WNT8A	VGNC	VGNC:78801
Mus musculus	WNT8A	MGD	MGI:107924
Felis catus	WNT8A	VGNC	VGNC:67085
Bos taurus	WNT8A	VGNC	VGNC:36964
Canis familiaris	WNT8A	VGNC	VGNC:48429
Others	WNT8A	NCBI